Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

DOI10.1098/rsta.2019.0348zbMath1470.92035OpenAlexW3027136194WikidataQ95651752 ScholiaQ95651752MaRDI QIDQ5154218

David J. Gavaghan, Teun P. de Boer, Chon Lok Lei, Dominic G. Whittaker, Michael Clerx, Gary R. Mirams

Publication date: 4 October 2021

Published in: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1098/rsta.2019.0348

zbMATH Keywords

variabilityuncertaintymathematical modellingcomputational biologybiophysicselectrophysiologybiomathematicsion channel

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biophysics (92C05)

Related Items (3)

Empirical quantification of predictive uncertainty due to model discrepancy by training with an ensemble of experimental designs: an application to ion channel kinetics ⋮ Modelling and simulation for preclinical cardiac safety assessment of drugs with human iPSC-derived cardiomyocytes ⋮ Considering discrepancy when calibrating a mechanistic electrophysiology model

Cites Work

• Extending the conditions of application of an inversion of the Hodgkin-Huxley gating model
• Considering discrepancy when calibrating a mechanistic electrophysiology model

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