On a reaction-cross-diffusion system modeling the growth of glioblastoma

DOI10.1137/18M1194559MaRDI QIDQ5208243zbMATH OpenWikidataFDO

Authors Martin Burger, Patricia Friele, Jan-Frederik Pietschmann

Publication date 15 January 2020

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1710.03970

zbMATH Keywords

glioblastomamathematical biologynumerical simulationspartial differential equationanalysis

Mathematics Subject Classification ID

Medical applications (general) (92C50) Initial value problems for second-order parabolic systems (35K45) Nonlinear parabolic equations (35K55) Degenerate parabolic equations (35K65) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Abstract: We investigate a recently proposed cross-diffusion system modelling the growth of gliobastoma taking into account size exclusion both in the migration and proliferation process. In addition to degenerate nonlinear cross-diffusion the model includes reaction terms as in the Fisher-Kolmogorov equation and linear ones modelling transition between states of proliferation and migration. We discuss the mathematical structure of the system and provide a complete existence analysis in spatial dimension one. The proof is based on exploiting partial entropy dissipation techniques and fully implicit time discretisations. In order to prove existence of the latter appropriate variational and fixed-point techniques are used, together with suitable a-priori estimates. Moreover, we review the existence of travelling waves and their relation to potential growth or decay of glioblastoma. Finally we provide extensive numerical studies in one and two spatial dimensions, including the effect of anisotropic diffusions as found in neural tissues.

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Cited in

(15)

• Modelling of glioblastoma growth by linking a molecular interaction network with an agent-based model
• A mathematical model of dynamic glioma–host interactions: receptor-mediated invasion and local proteolysis
• Density-dependent quiescence in glioma invasion: instability in a simple reaction–diffusion model for the migration/proliferation dichotomy
• Optimal Chemotherapy for Brain Tumor Growth in a Reaction-Diffusion Model
• Travelling wave solutions of the reaction-diffusion mathematical model of glioblastoma growth: an Abel equation based approach
• A numerical analysis of a reaction-diffusion system modeling the dynamics of growth tumors
• Estimating the extent of glioblastoma invasion. Approximate stationalization of anisotropic advection-diffusion-reaction equations in the context of glioblastoma invasion
• A data-motivated density-dependent diffusion model of in vitro glioblastoma growth
• The reaction-cross-diffusion models for tissue growth
• Tracking glioblastoma progression after initial resection with minimal reaction-diffusion models
• Existence of traveling wave solutions to data-driven glioblastoma multiforme growth models with density-dependent diffusion
• Entropy structure of a cross-diffusion tumor-growth model
• A hybrid model for cell proliferation and migration in glioblastoma
• Fast Reaction Limit with Nonmonotone Reaction Function
• Theoretical and numerical analysis for a hybrid tumor model with diffusion depending on vasculature

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