Efficient methods for signal detection from correlated adverse events in clinical trials

DOI10.1111/BIOM.13031MaRDI QIDQ5214577zbMATH OpenOpenAlexWikidataFDO

Authors

Publication date 7 February 2020

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/biom.13031

zbMATH Keywords

family-wise error ratepermutation testmultiplier bootstrapscore testRademacher sequence

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Measures of association (correlation, canonical correlation, etc.) (62H20) Signal theory (characterization, reconstruction, filtering, etc.) (94A12) Detection theory in information and communication theory (94A13)

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Cited in

(4)

• Likelihood-ratio-test methods for drug safety signal detection from multiple clinical datasets
• Detecting potential safety issues in clinical trials by Bayesian screening
• Bayesian approach for clinical trial safety data using an Ising prior
• A study of speedier signal detection for serious adverse events

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