Efficient methods for signal detection from correlated adverse events in clinical trials

DOI10.1111/BIOM.13031zbMATH Open1436.62539OpenAlexW2912429205WikidataQ91253116 ScholiaQ91253116MaRDI QIDQ5214577FDOQ5214577

Authors:

Publication date: 7 February 2020

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/biom.13031

Recommendations

• Detecting potential safety issues in clinical trials by Bayesian screening
• Accounting for multiplicity in the evaluation of ``signals obtained by data mining from spontaneous report adverse event databases
• A likelihood ratio test based method for signal detection with application to FDA's drug safety data
• A study of speedier signal detection for serious adverse events
• Likelihood-ratio-test methods for drug safety signal detection from multiple clinical datasets

zbMATH Keywords

family-wise error ratepermutation testmultiplier bootstrapscore testRademacher sequence

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Measures of association (correlation, canonical correlation, etc.) (62H20) Signal theory (characterization, reconstruction, filtering, etc.) (94A12) Detection theory in information and communication theory (94A13)

Cited In (4)

• Likelihood-ratio-test methods for drug safety signal detection from multiple clinical datasets
• Detecting potential safety issues in clinical trials by Bayesian screening
• Bayesian approach for clinical trial safety data using an Ising prior
• A study of speedier signal detection for serious adverse events

This page was built for publication: Efficient methods for signal detection from correlated adverse events in clinical trials

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5214577)