An analysis of a mathematical model describing acid-mediated tumor invasion

DOI10.1002/MMA.5772zbMATH Open1430.35114arXiv1902.02632OpenAlexW2961002427WikidataQ111492895 ScholiaQ111492895MaRDI QIDQ5214903FDOQ5214903

Authors: Luís F. Salvino, Anderson De Araújo, Artur César Fassoni 

Publication date: 5 February 2020

Published in: Mathematical Methods in the Applied Sciences (Search for Journal in Brave)

Abstract: We present a mathematical analysis of a reaction-diffusion model describing acid-mediated tumor invasion. The model describes the spatial distribution and temporal evolution of tumor cells, normal cells, and excess lactic acid concentration. The model assumes that tumor-induced alteration of microenvironmental pH provides a simple but complete mechanism for cancer invasion. We provide results on the existence and uniqueness of a solution considering Neumann and Dirichlet boundary conditions. We also provide numerical simulations to the solutions considering both boundary conditions.

Full work available at URL: https://arxiv.org/abs/1902.02632

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zbMATH Keywords

existence of solutionsnonlinear systemtumor growthacid-mediated tumor invasion

Mathematics Subject Classification ID

Medical applications (general) (92C50) Initial value problems for second-order parabolic systems (35K45) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37)

Cited In (24)

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• Mathematical analysis of a non-local mixed ODE-PDE model for tumor invasion and chemotherapy
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• A general reaction-diffusion model of acidity in cancer invasion
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• A model combining acid-mediated tumour invasion and nutrient dynamics
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