Model-free approach to quantifying the proportion of treatment effect explained by a surrogate marker

DOI10.1093/BIOMET/ASZ065MaRDI QIDQ5222223zbMATH OpenOpenAlexWikidataFDO

Authors Layla Parast, Lu Tian, Tianxi Cai, Xuan Wang

Publication date 1 April 2020

Published in Biometrika (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc7315285

zbMATH Keywords

nonparametric estimationrandomized clinical trialsurrogate markerproportion of treatment effect explained

Mathematics Subject Classification ID

Density estimation (62G07) Applications of statistics to biology and medical sciences; meta analysis (62P10) Sampling theory, sample surveys (62D05)

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• Quantifying the feasibility of shortening clinical trial duration using surrogate markers
• Power of testing for exposure effects under incomplete mediation
• Robust Approach to Combining Multiple Markers to Improve Surrogacy
• Evaluation of longitudinal surrogate markers
• A Measure of the Proportion of Treatment Effect Explained by a Surrogate Marker
• Assessing heterogeneity in surrogacy using censored data
• Quantifying direct and indirect effect for longitudinal mediator and survival outcome using joint modeling approach
• Evaluating multiple surrogate markers with censored data
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• Identifying surrogate markers in real-world comparative effectiveness research

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