Testing for Heterogeneity in the Utility of a Surrogate Marker

DOI10.1111/biom.13600zbMath1522.62212OpenAlexW4200119189MaRDI QIDQ6079768

L. Tian, Layla Parast, Tianxi Cai

Publication date: 30 October 2023

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/biom.13600

zbMATH Keywords

heterogeneitykernel methodspotential outcomestreatment effectnonparametric methodssurrogate marker

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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• Using a surrogate marker for early testing of a treatment effect
• Validation of Surrogate Endpoints in Multiple Randomized Clinical Trials with Discrete Outcomes
• Model-free approach to quantifying the proportion of treatment effect explained by a surrogate marker

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