On semiparametric estimation of a path-specific effect in the presence of mediator-outcome confounding
From MaRDI portal
(Redirected from Publication:5222226)
Abstract: Path-specific effects are a broad class of mediated effects from an exposure to an outcome via one or more causal pathways with respect to some subset of intermediate variables. The majority of the literature concerning estimation of mediated effects has focused on parametric models with stringent assumptions regarding unmeasured confounding. We consider semiparametric inference of a path-specific effect when these assumptions are relaxed. In particular, we develop a suite of semiparametric estimators for the effect along a pathway through a mediator, but not some exposure-induced confounder of that mediator. These estimators have different robustness properties, as each depends on different parts of the observed data likelihood. One of our estimators may be viewed as combining the others, because it is locally semiparametric efficient and multiply robust. The latter property is illustrated in a simulation study. We apply our methodology to an HIV study, in which we estimate the effect comparing two drug treatments on a patient's average log CD4 count mediated by the patient's level of adherence, but not by previous experience of toxicity, which is clearly affected by which treatment the patient is assigned to, and may confound the effect of the patient's level of adherence on their virologic outcome.
Recommendations
- Semiparametric theory for causal mediation analysis: efficiency bounds, multiple robustness and sensitivity analysis
- Estimation of Controlled Direct Effects
- Estimation of a semiparametric natural direct effect model incorporating baseline covariates
- Semiparametric Estimation of Treatment Effect in a Pretest‐Posttest Study
- Generalized causal mediation analysis
Cited in
(15)- Confounding in the estimation of mediation effects
- Causal Mediation for Survival Data: A Unifying Approach via GLM
- Semiparametric Causal Mediation Analysis with Unmeasured Mediator-Outcome Confounding
- Discussion on “Causal mediation of semicompeting risks” by Yen‐Tsung Huang
- Identification, Semiparametric Efficiency, and Quadruply Robust Estimation in Mediation Analysis with Treatment-Induced Confounding
- Causal mediation analysis with a three-dimensional image mediator
- Causal mediation analysis with sure outcomes of random events model
- Identification and robust estimation of swapped direct and indirect effects: mediation analysis with unmeasured mediator-outcome confounding and intermediate confounding
- Multiply robust estimation of natural indirect effects with multiple ordered mediators
- Identification and multiply robust estimation in causal mediation analysis across principal strata
- Nonparametric estimation of path-specific effects in the presence of nonignorable missing covariates
- Semiparametric theory for causal mediation analysis: efficiency bounds, multiple robustness and sensitivity analysis
- A Bayesian nonparametric approach for causal mediation with a post-treatment confounder
- Assessing racial disparities in healthcare expenditures via mediator distribution shifts
- Randomized interventional effects in semicompeting risks, with application to a hematopoietic cell transplantation study
This page was built for publication: On semiparametric estimation of a path-specific effect in the presence of mediator-outcome confounding
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5222226)
