Optimal control of a multi-level dynamic model for biofuel production
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Abstract: Dynamic flux balance analysis of a bioreactor is based on the coupling between a dynamic problem, which models the evolution of biomass, feeding substrates and metabolites, and a linear program, which encodes the metabolic activity inside cells. We cast the problem in the language of optimal control and propose a hybrid formulation to model the full coupling between macroscopic and microscopic level. On a given location of the hybrid system we analyze necessary conditions given by the Pontryagin Maximum Principle and discuss the presence of singular arcs. In particular, for the single-input case we prove that optimal controls are bang-bang. For the multi-input case, under suitable assumptions, we prove that generically with respect to initial conditions optimal controls are bang-bang.
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Cites work
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- scientific article; zbMATH DE number 1361612 (Why is no real title available?)
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- Optimal control of the chemotherapy of HIV
- Optimal control of treatments in a two-strain tuberculosis model
- Singular Trajectories of Control-Affine Systems
- Structural analysis of a core model for carbohydrate uptake in \textit{Escherichia coli}
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