Sample dispersion in isotachophoresis with Poiseuille counterflow

DOI10.1063/1.4789967zbMATH Open1315.76043arXiv1206.1707OpenAlexW3105788791MaRDI QIDQ5261793FDOQ5261793

Somnath Bhattacharyya, Partha P. Gopmandal, Steffen Hardt, Tobias Baier

Publication date: 7 July 2015

Published in: Physics of Fluids (Search for Journal in Brave)

Abstract: A particular mode of isotachophoresis (ITP) employs a pressure-driven flow opposite to the sample electromigration direction in order to anchor a sample zone at a specific position along a channel or capillary. We investigate this situation using a two-dimensional finite-volume model based on the Nernst-Planck equation. The imposed Poiseuille flow profile leads to a significant dispersion of the sample zone. This effect is detrimental for the resolution in analytical applications of ITP. We investigate the impact of convective dispersion, characterized by the area-averaged width of a sample zone, for various values of the sample P'{e}clet-number, as well as the relative mobilities of the sample and the adjacent electrolytes. A one-dimensional model for the area-averaged concentrations based on a Taylor-Aris-type effective axial diffusivity is shown to yield good agreement with the finite-volume calculations. This justifies the use of such simple models and opens the door for the rapid simulation of ITP protocols with Poiseuille counterflow.

Full work available at URL: https://arxiv.org/abs/1206.1707

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Mathematics Subject Classification ID

Magnetohydrodynamics and electrohydrodynamics (76W05) Finite volume methods applied to problems in fluid mechanics (76M12)

Cites Work

• A stable and accurate convective modelling procedure based on quadratic upstream interpolation
• Instability of electrokinetic microchannel flows with conductivity gradients
• Analytical approximations to the flow field induced by electroosmosis during isotachophoretic transport through a channel
• Sample dispersion in isotachophoresis
• Transition zone dynamics in combined isotachophoretic and electro-osmotic transport

Cited In (3)

• Dynamics of field-amplified sample stacking
• Title not available (Why is that?)
• Shear dispersion of multispecies electrolyte solutions in the channel domain

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