Augmented Designs to Assess Immune Response in Vaccine Trials

DOI10.1111/J.1541-0420.2006.00569.XzbMath1114.62116OpenAlexW2057033518WikidataQ36877243 ScholiaQ36877243MaRDI QIDQ5295377

Dean A. Follmann

Publication date: 27 July 2007

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc2536776

zbMATH Keywords

AIDSmissing datacounterfactualcausal inferenceprincipal stratificationsurrogate endpointcorrelate of protection

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical epidemiology (92C60)

Related Items (18)

Comparing Biomarkers as Principal Surrogate Endpoints ⋮ Incorporating founder virus information in vaccine field trials ⋮ Sensitivity analysis for evaluating principal surrogate endpoints relaxing the equal early clinical risk assumption ⋮ A unified evaluation of differential vaccine efficacy ⋮ Solutions for Surrogacy Validation with Longitudinal Outcomes for a Gene Therapy ⋮ Assurance in vaccine efficacy clinical trial design based on immunological responses ⋮ Evaluating Candidate Principal Surrogate Endpoints ⋮ A Bayesian Approach to Improved Estimation of Causal Effect Predictiveness for a Principal Surrogate Endpoint ⋮ Predicting overall vaccine efficacy in a new setting by re-calibrating baseline covariate and intermediate response endpoint effect modifiers of type-specific vaccine efficacy ⋮ Assessing surrogate endpoints in vaccine trials with case-cohort sampling and the Cox model ⋮ Statistical Identifiability and the Surrogate Endpoint Problem, with Application to Vaccine Trials ⋮ A Multiple Imputation Approach for the Evaluation of Surrogate Markers in the Principal Stratification Causal Inference Framework ⋮ Augmented Designs to Assess Principal Strata Direct Effects ⋮ Identification of causal effects within principal strata using auxiliary variables ⋮ Design and Estimation for Evaluating Principal Surrogate Markers in Vaccine Trials ⋮ Evaluating principal surrogate markers in vaccine trials in the presence of multiphase sampling ⋮ Assessing Vaccine Effects in Repeated Low‐Dose Challenge Experiments ⋮ Surrogate Measures and Consistent Surrogates

Cites Work

• Bayesian inference for causal effects: The role of randomization
• Bayesian Inference on Protective Antibody Levels Using Case‐Control Data
• Principal Stratification in Causal Inference
• Sensitivity Analysis for the Assessment of Causal Vaccine Effects on Viral Load in HIV Vaccine Trials
• On the Effect of Treatment among Would-Be Treatment Compliers: An Analysis of the Multiple Risk Factor Intervention Trial

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