Asymptotic properties of mathematical models of excitability
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Publication:5301883
DOI10.1098/RSTA.2006.1770zbMATH Open1152.37348arXivnlin/0508020OpenAlexW2147805564WikidataQ51943912 ScholiaQ51943912MaRDI QIDQ5301883FDOQ5301883
Authors: I. V. Biktasheva, R. Suckley, V. N. Biktashev, Radostin D. Simitev 
Publication date: 20 January 2009
Published in: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)
Abstract: We analyse small parameters in selected models of biological excitability, including Hodgkin-Huxley (1952) model of nerve axon, Noble (1962) model of heart Purkinje fibres, and Courtemanche et al. (1998) model of human atrial cells. Some of the small parameters are responsible for differences in the characteristic timescales of dynamic variables, as in the traditional singular perturbation approaches. Others appear in a way which makes the standard approaches inapplicable. We apply this analysis to study the behaviour of fronts of excitation waves in spatially-extended cardiac models. Suppressing the excitability of the tissue leads to a decrease in the propagation speed, but only to a certain limit; further suppression blocks active propagation and leads to a passive diffusive spread of voltage. Such a dissipation may happen if a front propagates into a tissue recovering after a previous wave, e.g. re-entry. A dissipated front does not recover even when the excitability restores. This has no analogy in FitzHugh-Nagumo model and its variants, where fronts can stop and then start again. In two spatial dimensions, dissipation accounts for break-ups and self-termination of re-entrant waves in excitable media with Courtemanche et al. (1998) kinetics.
Full work available at URL: https://arxiv.org/abs/nlin/0508020
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Cites Work
Cited In (7)
- Asymptotics of conduction velocity restitution in models of electrical excitation in the heart
- A method of `speed coefficients' for biochemical model reduction applied to the NF-\(\kappa\)B system
- Fast-slow asymptotics for a Markov chain model of fast sodium current
- A SIMPLIFIED MODEL OF PROPAGATION AND DISSIPATION OF EXCITATION FRONTS
- DISSIPATION OF THE EXCITATION FRONT AS A MECHANISM OF SELF-TERMINATING ARRHYTHMIAS
- Asymptotic analysis and analytical solutions of a model of cardiac excitation
- Propagation and Its Failure in Coupled Systems of Discrete Excitable Cells
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