Asymptotic analysis and analytical solutions of a model of cardiac excitation

DOI10.1007/S11538-007-9267-0zbMATH Open1139.92006arXivq-bio/0607047OpenAlexW2129514645WikidataQ51898999 ScholiaQ51898999MaRDI QIDQ932040FDOQ932040

Authors: V. N. Biktashev, R. Suckley, Yu. E. Elkin, Radostin D. Simitev 

Publication date: 8 July 2008

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: We describe an asymptotic approach to gated ionic models of single-cell cardiac excitability. It has a form essentially different from the Tikhonov fast-slow form assumed in standard asymptotic reductions of excitable systems. This is of interest since the standard approaches have been previously found inadequate to describe phenomena such as the dissipation of cardiac wave fronts and the shape of action potential at repolarization. The proposed asymptotic description overcomes these deficiencies by allowing, among other non-Tikhonov features, that a dynamical variable may change its character from fast to slow within a single solution. The general asymptotic approach is best demonstrated on an example which should be both simple and generic. The classical model of Purkinje fibers (Noble, 1962) has the simplest functional form of all cardiac models but according to the current understanding it assigns a physiologically incorrect role to the Na current. This leads us to suggest an ``Archetypal Model with the simplicity of the Noble model but with a structure more typical to contemporary cardiac models. We demonstrate that the Archetypal Model admits a complete asymptotic solution in quadratures. To validate our asymptotic approach, we proceed to consider an exactly solvable ``caricature of the Archetypal Model and demonstrate that the asymptotic of its exact solution coincides with the solutions obtained by substituting the ``caricature right-hand sides into the asymptotic solution of the generic Archetypal Model. This is necessary, because, unlike in standard asymptotic descriptions, no general results exist which can guarantee the proximity of the non-Tikhonov asymptotic solutions to the solutions of the corresponding detailed ionic model.

Full work available at URL: https://arxiv.org/abs/q-bio/0607047

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zbMATH Keywords

action potentialordinary differential equationssingular perturbationsasymptotic methodsexcitability

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Physiology (general) (92C30) Biophysics (92C05)

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Cited In (12)

• Model selection via marginal likelihood estimation by combining thermodynamic integration and gradient matching
• Shortening of cardiac action potential duration near an insulating boundary
• Asymptotic approximation of an ionic model for cardiac restitution
• A predictive method allowing the use of a single ionic model in numerical cardiac electrophysiology
• Asymptotics of conduction velocity restitution in models of electrical excitation in the heart
• Fast-slow asymptotics for a Markov chain model of fast sodium current
• A linear system of partial differential equations modeling the resting potential of a heart with regional ischemia
• Asymptotic properties of mathematical models of excitability
• Two-Term Asymptotic Approximation of a Cardiac Restitution Curve
• Understanding broad-spike oscillations in a model of intracellular calcium dynamics
• Two-scale asymptotic analysis for modeling activation of periodic cardiac strand
• THE ASYMPTOTIC STRUCTURE OF THE HODGKIN–HUXLEY EQUATIONS

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