Stochastic equations for a self-regulating gene

DOI10.1142/S1793524517500462zbMATH Open1373.92047arXiv1403.3265MaRDI QIDQ5347494FDOQ5347494

Authors: Martin Jansen 

Publication date: 24 May 2017

Published in: International Journal of Biomathematics (Search for Journal in Brave)

Abstract: Expression of cellular genes is regulated by binding of transcription factors to their promoter, either activating or inhibiting transcription of a gene. Particularly interesting is the case when the expressed protein regulates its own transcription. In this paper the features of this self-regulating process are investigated. In the here presented model the gene can be in two states. Either a protein is bound to its promoter or not. The steady state distributions of protein during and at the end of both states are analyzed. Moreover a powerful numerical method based on the corresponding master equation to compute the protein distribution in the steady state is presented and compared to an already existing method. Additionally the special case of self-regulation, in which protein can only be produced, if one of these proteins is bound to the promoter region, is analyzed. Furthermore a self-regulating gene is compared to a similar gene, which also has two states and produces the same amount of proteins but is not regulated by its protein-product.

Full work available at URL: https://arxiv.org/abs/1403.3265

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zbMATH Keywords

gene expressiongene regulatory networksmaster equationchemical reaction networkactivated gene

Mathematics Subject Classification ID

Applications of continuous-time Markov processes on discrete state spaces (60J28) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Cites Work

• Title not available (Why is that?)
• Computing the confluent hypergeometric function, \(M(a,b,x)\)
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Cited In (11)

• Title not available (Why is that?)
• Stochastic regulation of gene expression
• Inference on autoregulation in gene expression with variance-to-mean ratio
• Theoretical study of the one self-regulating gene in the modified Wagner model
• Interplay of bistable kinetics of gene expression during cellular growth
• Stationary distributions and metastable behaviour for self-regulating proteins with general lifetime distributions
• Self-regulation of gene activity with structural transition of a giant DNA
• Stochastic analysis of autoregulatory gene expression dynamics
• Gene expression in self-repressing system with multiple gene copies
• Bistable switching asymptotics for the self regulating gene
• Stochastic models and numerical algorithms for a class of regulatory gene networks

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