Stochastic equations for a self-regulating gene

DOI10.1142/S1793524517500462MaRDI QIDQ5347494zbMATH OpenFDO

Authors Martin Jansen

Publication date 24 May 2017

Published in International Journal of Biomathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1403.3265

zbMATH Keywords

activated genechemical reaction networkgene expressiongene regulatory networksmaster equation

Mathematics Subject Classification ID

Applications of continuous-time Markov processes on discrete state spaces (60J28) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Abstract: Expression of cellular genes is regulated by binding of transcription factors to their promoter, either activating or inhibiting transcription of a gene. Particularly interesting is the case when the expressed protein regulates its own transcription. In this paper the features of this self-regulating process are investigated. In the here presented model the gene can be in two states. Either a protein is bound to its promoter or not. The steady state distributions of protein during and at the end of both states are analyzed. Moreover a powerful numerical method based on the corresponding master equation to compute the protein distribution in the steady state is presented and compared to an already existing method. Additionally the special case of self-regulation, in which protein can only be produced, if one of these proteins is bound to the promoter region, is analyzed. Furthermore a self-regulating gene is compared to a similar gene, which also has two states and produces the same amount of proteins but is not regulated by its protein-product.

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Cites work

• Computing the confluent hypergeometric function, M(a,b,x)
• scientific article; zbMATH DE number 3273551 (Why is no real title available?)
• Markovian modelling of gene product synthesis

Cited in

(18)

• Theoretical study of the one self-regulating gene in the modified Wagner model
• Stochastic modeling of gene activation and applications to cell regulation
• Stationary distributions and metastable behaviour for self-regulating proteins with general lifetime distributions
• Transcriptional stochasticity in gene expression
• Justification of quasi-stationary approximation in models of gene expression of a self-regulating protein
• A stochastic analysis of autoregulation of gene expression
• Stochastic regulation of gene expression
• On spins and genes
• Stochastic analysis of autoregulatory gene expression dynamics
• Self-regulation of gene activity with structural transition of a giant DNA
• Interplay of bistable kinetics of gene expression during cellular growth
• Gene expression in self-repressing system with multiple gene copies
• scientific article; zbMATH DE number 1568295 (Why is no real title available?)
• Bistable switching asymptotics for the self regulating gene
• Inference on autoregulation in gene expression with variance-to-mean ratio
• Mathematical aspects of the regulation of gene transcription by promoters
• Stochastic effects of multiple regulators on expression profiles in eukaryotes
• Stochastic models and numerical algorithms for a class of regulatory gene networks

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