A stochastic analysis of autoregulation of gene expression

DOI10.1007/S00285-017-1116-7MaRDI QIDQ2409176zbMATH OpenOpenAlexWikidataFDO

Authors Renaud Dessalles, V. Fromion, Philippe Robert

Publication date 11 October 2017

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1509.02045

zbMATH Keywords

autoregulationmRNAsrepressorsstochastic variability

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Cell biology (92C37) Biochemistry, molecular biology (92C40)

Abstract: This paper analyzes, in the context of a prokaryotic cell, the stochastic variability of the number of proteins when there is a control of gene expression by an autoregulation scheme. The goal of this work is to estimate the efficiency of the regulation to limit the fluctuations of the number of copies of a given protein. The autoregulation considered in this paper relies mainly on a negative feedback: the proteins are repressors of their own gene expression. The efficiency of a production process without feedback control is compared to a production process with an autoregulation of the gene expression assuming that both of them produce the same average number of proteins. The main characteristic used for the comparison is the standard deviation of the number of proteins at equilibrium. With a Markovian representation and a simple model of repression, we prove that, under a scaling regime, the repression mechanism follows a Hill repression scheme with an hyperbolic control. An explicit asymptotic expression of the variance of the number of proteins under this regulation mechanism is obtained. Simulations are used to study other aspects of autoregulation such as the rate of convergence to equilibrium of the production process and the case where the control of the production process of proteins is achieved via the inhibition of mRNAs.

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Cited in

(22)

• Exact steady-state distributions of multispecies birth-death-immigration processes: effects of mutations and carrying capacity on diversity
• Theoretical study of the one self-regulating gene in the modified Wagner model
• High cooperativity in negative feedback can amplify noisy gene expression
• Limits of noise for autoregulated gene expression
• Negative feedback and physical limits of genes
• Stochastic analysis of a complex gene-expression model
• Approximate solutions to the response time problems of transcription autoregulatory gene networks
• Noise dissipation in gene regulatory networks via second order statistics of networks of infinite server queues
• Dynamic responses of protein homeostatic regulatory mechanisms to perturbations from steady state
• External noise and feedback regulation: steady-state statistics of auto-regulatory genetic network
• Application of the Goodwin model to autoregulatory feedback for stochastic gene expression
• Stochastic regulation of gene expression
• Stochastic analysis of autoregulatory gene expression dynamics
• Gene expression in self-repressing system with multiple gene copies
• Probabilistic and piecewise deterministic models in biology
• Stochastic equations for a self-regulating gene
• Heavy-tailed distributions in a stochastic gene autoregulation model
• Inference on autoregulation in gene expression with variance-to-mean ratio
• Stochastic models of regulation of transcription in biological cells
• Self‐regulation in a stochastic model of chemical self‐replication
• Autoregulation of transcription and translation: a qualitative analysis
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