Negative feedback and physical limits of genes
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Publication:1786036
Abstract: This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost. The analysis shows that, in the case of non-vanishing leak expression rate, the negative feedback reduces both the switching on and switching off times of a gene. The noise of the auto-repressed gene will be lower than the one of the simple gene only for low leak expression rates. Summing up, for low, but non-vanishing leak expression rates, the auto-repressed gene is both faster and less noisier compared to the simple one.
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Cites work
- Logical Reversibility of Computation
- Mathematical biology. Vol. 1: An introduction.
- Models of transcription factor binding: sensitivity of activation functions to model assumptions
- Stochastic processes in physics and chemistry.
- Stochasticity in single gene expression with both intrinsic noise and fluctuation in kinetic parameters
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