Adiabatic reduction of a model of stochastic gene expression with jump Markov process

DOI10.1007/S00285-013-0661-YzbMATH Open1284.92031arXiv1202.5411OpenAlexW2126217289WikidataQ51249753 ScholiaQ51249753MaRDI QIDQ2447544FDOQ2447544

Authors: R. Yvinec, Changjing Zhuge, Jinzhi Lei, M. C. Mackey 

Publication date: 28 April 2014

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: This paper considers adiabatic reduction in a model of stochastic gene expression with bursting transcription considered as a jump Markov process. In this model, the process of gene expression with auto-regulation is described by fast/slow dynamics. The production of mRNA is assumed to follow a compound Poisson process occurring at a rate depending on protein levels (the phenomena called bursting in molecular biology) and the production of protein is a linear function of mRNA numbers. When the dynamics of mRNA is assumed to be a fast process (due to faster mRNA degradation than that of protein) we prove that, with appropriate scalings in the burst rate, jump size or translational rate, the bursting phenomena can be transmitted to the slow variable. We show that, depending on the scaling, the reduced equation is either a stochastic differential equation with a jump Poisson process or a deterministic ordinary differential equation. These results are significant because adiabatic reduction techniques seem to have not been rigorously justified for a stochastic differential system containing a jump Markov process. We expect that the results can be generalized to adiabatic methods in more general stochastic hybrid systems.

Full work available at URL: https://arxiv.org/abs/1202.5411

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zbMATH Keywords

scaling limitsquasi-steady state assumptionpiecewise deterministic Markov processesstochastic bursting gene expressions

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Qualitative investigation and simulation of ordinary differential equation models (34C60)

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Cited In (11)

• Stochastic switching in biology: from genotype to phenotype
• A stochastic analysis of autoregulation of gene expression
• Influence of gene copy number on self-regulated gene expression
• Transcriptional bursting diversifies the behaviour of a toggle switch: hybrid simulation of stochastic gene expression
• Spectral expansions of non-self-adjoint generalized Laguerre semigroups
• The competitive exclusion principle in stochastic environments
• Some simple but challenging Markov processes
• Existence of invariant densities for semiflows with jumps
• Application of the Goodwin model to autoregulatory feedback for stochastic gene expression
• Effects of elongation delay in transcription dynamics
• Probabilistic and piecewise deterministic models in biology

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