Adiabatic reduction of a model of stochastic gene expression with jump Markov process
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Publication:2447544
Abstract: This paper considers adiabatic reduction in a model of stochastic gene expression with bursting transcription considered as a jump Markov process. In this model, the process of gene expression with auto-regulation is described by fast/slow dynamics. The production of mRNA is assumed to follow a compound Poisson process occurring at a rate depending on protein levels (the phenomena called bursting in molecular biology) and the production of protein is a linear function of mRNA numbers. When the dynamics of mRNA is assumed to be a fast process (due to faster mRNA degradation than that of protein) we prove that, with appropriate scalings in the burst rate, jump size or translational rate, the bursting phenomena can be transmitted to the slow variable. We show that, depending on the scaling, the reduced equation is either a stochastic differential equation with a jump Poisson process or a deterministic ordinary differential equation. These results are significant because adiabatic reduction techniques seem to have not been rigorously justified for a stochastic differential system containing a jump Markov process. We expect that the results can be generalized to adiabatic methods in more general stochastic hybrid systems.
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Cited in
(11)- Application of the Goodwin model to autoregulatory feedback for stochastic gene expression
- The competitive exclusion principle in stochastic environments
- A stochastic analysis of autoregulation of gene expression
- Effects of elongation delay in transcription dynamics
- Stochastic switching in biology: from genotype to phenotype
- Transcriptional bursting diversifies the behaviour of a toggle switch: hybrid simulation of stochastic gene expression
- Probabilistic and piecewise deterministic models in biology
- Spectral expansions of non-self-adjoint generalized Laguerre semigroups
- Some simple but challenging Markov processes
- Influence of gene copy number on self-regulated gene expression
- Existence of invariant densities for semiflows with jumps
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