Molecular distributions in gene regulatory dynamics
From MaRDI portal
Publication:5963480
Abstract: We show how one may analytically compute the stationary density of the distribution of molecular constituents in populations of cells in the presence of noise arising from either bursting transcription or translation, or noise in degradation rates arising from low numbers of molecules. We have compared our results with an analysis of the same model systems (either inducible or repressible operons) in the absence of any stochastic effects, and shown the correspondence between behaviour in the deterministic system and the stochastic analogs. We have identified key dimensionless parameters that control the appearance of one or two steady states in the deterministic case, or unimodal and bimodal densities in the stochastic systems, and detailed the analytic requirements for the occurrence of different behaviours. This approach provides, in some situations, an alternative to computationally intensive stochastic simulations. Our results indicate that, within the context of the simple models we have examined, bursting and degradation noise cannot be distinguished analytically when present alone.
Recommendations
- Distribution profiles and their dynamic transition in stochastic gene transcription
- Distribution modes and their corresponding parameter regions in stochastic gene transcription
- Modeling stochasticity in gene regulation: Characterization in the terms of the underlying distribution function
- Exact distributions for stochastic models of gene expression with arbitrary regulation
- Multiscale stochastic modelling of gene expression
- Stochastic analysis of autoregulatory gene expression dynamics
- Dynamics of gene regulatory networks with stochastic propensities
- Stochastic modelling of gene regulatory networks
- Stochastic regulation of gene expression
- Deterministic and stochastic descriptions of gene expression dynamics
Cites work
- scientific article; zbMATH DE number 1201579 (Why is no real title available?)
- scientific article; zbMATH DE number 758785 (Why is no real title available?)
- Asymptotic behavior of distributions of mRNA and protein levels in a model of stochastic gene expression
- Chaos, fractals, and noise: Stochastic aspects of dynamics.
- Comparing different ODE modelling approaches for gene regulatory networks
- Continuous Markov semigroups and stability of transport equations
- Dynamics and bistability in a reduced model of the lac operon
- Dynamics and density evolution in piecewise deterministic growth processes
- Estimations of intrinsic and extrinsic noise in models of nonlinear genetic networks
- Extrinsic noise passing through a Michaelis-Menten reaction: a universal response of a genetic switch
- Mathematical Analysis of a Cellular Control Process with Positive Feedback
- Noise-induced transitions. Theory and applications in physics, chemistry, and biology
- Predicting the asymmetric response of a genetic switch to noise
- Singular boundaries in the forward Chapman-Kolmogorov differential equation
- Synergetics. An introduction. Nonequilibrium phase transitions and self-organization in physics, chemistry, and biology. 3rd rev. and enl. ed
- The qualitative dynamics of a class of biochemical control circuits
- Theory of selforganization and evolution: The role of entropy, value and information
- Transcriptional stochasticity in gene expression
Cited in
(22)- A model of gene expression based on random dynamical systems reveals modularity properties of gene regulatory networks
- Exponential equilibration of genetic circuits using entropy methods
- Existence of a unique invariant measure for a class of equicontinuous Markov operators with application to a stochastic model for an autoregulated gene
- The combined effects of Feller diffusion and transcriptional/translational bursting in simple gene networks
- Stochastic modeling and numerical simulation of gene regulatory networks with protein bursting
- Gene expression noise is affected differentially by feedback in burst frequency and burst size
- Bounded noise induced first-order phase transitions in a baseline non-spatial model of gene transcription
- The limiting dynamics of a bistable molecular switch with and without noise
- Adiabatic reduction of a model of stochastic gene expression with jump Markov process
- Influence of gene copy number on self-regulated gene expression
- Transcriptional bursting diversifies the behaviour of a toggle switch: hybrid simulation of stochastic gene expression
- Noise dissipation in gene regulatory networks via second order statistics of networks of infinite server queues
- Existence of invariant densities for semiflows with jumps
- Application of the Goodwin model to autoregulatory feedback for stochastic gene expression
- Likelihood for transcriptions in a genetic regulatory system under asymmetric stable Lévy noise
- Type of noise defines global attractors in bistable molecular regulatory systems
- Stationary distributions and metastable behaviour for self-regulating proteins with general lifetime distributions
- Asymptotic behavior of a delayed stochastic logistic model with impulsive perturbations
- Regulatory Signals in Genomic Sequences
- Mathematical model of GAL regulon dynamics in \textit{Saccharomyces cerevisiae}
- Ergodicity and stability of a dynamical system perturbed by impulsive random interventions
- Analytical results for a non-Markovian process of gene expression with positive and negative feedbacks
This page was built for publication: Molecular distributions in gene regulatory dynamics
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5963480)
