Likelihood for transcriptions in a genetic regulatory system under asymmetric stable Lévy noise

DOI10.1063/1.5010026MaRDI QIDQ4565908zbMATH OpenOpenAlexWikidataFDO

Authors Hui Wang, Xiujun Cheng, Xiaofan Li, Jinqiao Duan, J. Kurths

Publication date 13 June 2018

Published in Chaos: An Interdisciplinary Journal of Nonlinear Science (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1705.06479

zbMATH Keywords

first escape probabilityLévy noisemean first exit time

Mathematics Subject Classification ID

Applications of stochastic analysis (to PDEs, etc.) (60H30) Biochemistry, molecular biology (92C40)

Abstract: This work is devoted to investigating the evolution of concentration in a genetic regulation system, when the synthesis reaction rate is under additive and multiplicative asymmetric stable L'evy fluctuations. By focusing on the impact of skewness (i.e., non-symmetry) in the probability distributions of noise, we find that via examining the mean first exit time (MFET) and the first escape probability (FEP), the asymmetric fluctuations, interacting with nonlinearity in the system, lead to peculiar likelihood for transcription. This includes, in the additive noise case, realizing higher likelihood of transcription for larger positive skewness (i.e., asymmetry) index $$, causing a stochastic bifurcation at the non-Gaussianity index value $alpha=1$ (i.e., it is a separating point or line for the likelihood for transcription), and achieving a turning point at the threshold value $$ (i.e., beyond which the likelihood for transcription suddenly reversed for $alpha$ values). The stochastic bifurcation and turning point phenomena do not occur in the symmetric noise case ($$). While in the multiplicative noise case, non-Gaussianity index value $alpha=1$ is a separating point or line for both the mean first exit time (MFET) and the first escape probability (FEP). We also investigate the noise enhanced stability phenomenon. Additionally, we are able to specify the regions in the whole parameter space for the asymmetric noise, in which we attain desired likelihood for transcription. We have conducted a series of numerical experiments in `regulating' the likelihood of gene transcription by tuning asymmetric stable L'evy noise indexes. This work offers insights for possible ways of achieving gene regulation in experimental research.

Recommendations

• Nonlocal dynamics in a gene regulatory system with tempered stable Lévy noise
• Stability of a gene transcriptional regulatory system under non-Gaussian noise
• Lévy noise induced transition and enhanced stability in a gene regulatory network
• Molecular distributions in gene regulatory dynamics
• Switches in a genetic regulatory system under multiplicative non-Gaussian noise

Cites work

• An introduction to stochastic dynamics
• Effects of Lévy noise on the dynamics of sine-Gordon solitons in long Josephson junctions
• First exit times for Lévy-driven diffusions with exponentially light jumps
• Foundations of synergetics. II: Complex patterns
• scientific article; zbMATH DE number 1639856 (Why is no real title available?)
• scientific article; zbMATH DE number 1402217 (Why is no real title available?)
• Langevin approach to Lévy flights in fixed potentials: exact results for stationary probability distributions
• LÉVY FLIGHT SUPERDIFFUSION: AN INTRODUCTION
• Lévy Processes and Stochastic Calculus
• Mean exit time and escape probability for dynamical systems driven by Lévy noises
• Stochastic processes in cell biology
• Stochastic regulation of gene expression
• Using gene expression noise to understand gene regulation

Cited in

(13)

• Switches in a genetic regulatory system under multiplicative non-Gaussian noise
• Most probable dynamics of a genetic regulatory network under stable Lévy noise
• Stability of a gene transcriptional regulatory system under non-Gaussian noise
• Bogdanov-Takens and Hopf bifurcations analysis of a genetic regulatory network
• Impacts of the cross-correlated noises on the fluctuation behaviors of a gene transcriptional regulatory system
• Realizing the transformation of logic gates in a genetic toggle system under Lévy noise
• Nonlocal dynamics for non-Gaussian systems arising in biophysical modeling
• Data-driven method to learn the most probable transition pathway and stochastic differential equation
• Lévy noise-driven escape from arctangent potential wells
• The Onsager–Machlup function as Lagrangian for the most probable path of a jump-diffusion process
• Dynamical transition of phenotypic states in breast cancer system with Lévy noise
• Detecting stochastic governing laws with observation on stationary distributions
• Data-driven method to extract mean exit time and escape probability for dynamical systems driven by Lévy noises

This page was built for publication: Likelihood for transcriptions in a genetic regulatory system under asymmetric stable Lévy noise

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4565908)