The limiting dynamics of a bistable molecular switch with and without noise

DOI10.1007/S00285-015-0949-1MaRDI QIDQ304043zbMATH OpenOpenAlexWikidataFDO

Authors M. C. Mackey, M. Tyran-Kamińska

Publication date 23 August 2016

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1512.00695

zbMATH Keywords

stochastic modellingbistable switchmutual repression

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Qualitative investigation and simulation of ordinary differential equation models (34C60) Continuous-time Markov processes on general state spaces (60J25)

Abstract: We consider the dynamics of a population of organisms containing two mutually inhibitory gene regulatory networks, that can result in a bistable switch-like behaviour. We completely characterize their local and global dynamics in the absence of any noise, and then go on to consider the effects of either noise coming from bursting (transcription or translation), or Gaussian noise in molecular degradation rates when there is a dominant slow variable in the system. We show analytically how the steady state distribution in the population can range from a single unimodal distribution through a bimodal distribution and give the explicit analytic form for the invariant stationary density which is globally asymptotically stable. Rather remarkably, the behaviour of the stationary density with respect to the parameters characterizing the molecular behaviour of the bistable switch is qualitatively identical in the presence of noise coming from bursting as well as in the presence of Gaussian noise in the degradation rate. This implies that one cannot distinguish between either the dominant source or nature of noise based on the stationary molecular distribution in a population of cells. We finally show that the switch model with bursting but two dominant slow genes has an asymptotically stable stationary density.

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Cited in

(13)

• Gene circuit designs for noisy excitable dynamics
• Intrinsic uncertainty in gene regulation network
• Predicting the asymmetric response of a genetic switch to noise
• Gene expression noise is affected differentially by feedback in burst frequency and burst size
• Bounded noise induced first-order phase transitions in a baseline non-spatial model of gene transcription
• Monostability and bistability of biological switches
• A kinetic finite volume discretization of the multidimensional PIDE model for gene regulatory networks
• Analytical study of an exclusive genetic switch
• Type of noise defines global attractors in bistable molecular regulatory systems
• Stationary distributions and metastable behaviour for self-regulating proteins with general lifetime distributions
• Postponing production exponentially enhances the molecular memory of a stochastic switch
• Dynamics of a simple regulatory switch
• Bimodality in gene expression without feedback: from Gaussian white noise to log-normal coloured noise

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