The limiting dynamics of a bistable molecular switch with and without noise

DOI10.1007/S00285-015-0949-1zbMATH Open1366.34067arXiv1512.00695OpenAlexW2184213955WikidataQ50750676 ScholiaQ50750676MaRDI QIDQ304043FDOQ304043

M. C. Mackey, M. Tyran-Kamińska

Publication date: 23 August 2016

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We consider the dynamics of a population of organisms containing two mutually inhibitory gene regulatory networks, that can result in a bistable switch-like behaviour. We completely characterize their local and global dynamics in the absence of any noise, and then go on to consider the effects of either noise coming from bursting (transcription or translation), or Gaussian noise in molecular degradation rates when there is a dominant slow variable in the system. We show analytically how the steady state distribution in the population can range from a single unimodal distribution through a bimodal distribution and give the explicit analytic form for the invariant stationary density which is globally asymptotically stable. Rather remarkably, the behaviour of the stationary density with respect to the parameters characterizing the molecular behaviour of the bistable switch is qualitatively identical in the presence of noise coming from bursting as well as in the presence of Gaussian noise in the degradation rate. This implies that one cannot distinguish between either the dominant source or nature of noise based on the stationary molecular distribution in a population of cells. We finally show that the switch model with bursting but two dominant slow genes has an asymptotically stable stationary density.

Full work available at URL: https://arxiv.org/abs/1512.00695

zbMATH Keywords

stochastic modellingbistable switchmutual repression

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Qualitative investigation and simulation of ordinary differential equation models (34C60) Continuous-time Markov processes on general state spaces (60J25)

Cites Work

• Title not available (Why is that?)
• Title not available (Why is that?)
• Title not available (Why is that?)
• Chaos, fractals, and noise: Stochastic aspects of dynamics.
• Comparing different ODE modelling approaches for gene regulatory networks
• Molecular distributions in gene regulatory dynamics
• Substochastic semigroups and densities of piecewise deterministic Markov processes
• Minimum embedding of a \(P_{4}\)-design into a balanced incomplete block design of index \(\lambda \)
• The qualitative dynamics of a class of biochemical control circuits
• Continuous Markov semigroups and stability of transport equations
• Designer gene networks: Towards fundamental cellular control
• Dynamics and density evolution in piecewise deterministic growth processes
• Transcriptional bursting diversifies the behaviour of a toggle switch: hybrid simulation of stochastic gene expression
• Mathematical Analysis of a Cellular Control Process with Positive Feedback
• Synergetics. An introduction. Nonequilibrium phase transitions and self-organization in physics, chemistry, and biology. 3rd rev. and enl. ed

Cited In (3)

• Gene expression noise is affected differentially by feedback in burst frequency and burst size
• A kinetic finite volume discretization of the multidimensional PIDE model for gene regulatory networks
• Postponing production exponentially enhances the molecular memory of a stochastic switch

This page was built for publication: The limiting dynamics of a bistable molecular switch with and without noise

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q304043)