Learning quadratic receptive fields from neural responses to natural stimuli

DOI10.1162/NECO_A_00463zbMATH Open1448.92048DBLPjournals/neco/RajanMT13arXiv1209.0121OpenAlexW2117026160WikidataQ38100825 ScholiaQ38100825MaRDI QIDQ5378221FDOQ5378221

Authors: Kanaka Rajan, Olivier Marre, Gašper Tkačik 

Publication date: 12 June 2019

Published in: Neural Computation (Search for Journal in Brave)

Abstract: Models of neural responses to stimuli with complex spatiotemporal correlation structure often assume that neurons are only selective for a small number of linear projections of a potentially high-dimensional input. Here we explore recent modeling approaches where the neural response depends on the quadratic form of the input rather than on its linear projection, that is, the neuron is sensitive to the local covariance structure of the signal preceding the spike. To infer this quadratic dependence in the presence of arbitrary (e.g. naturalistic) stimulus distribution, we review several inference methods, focussing in particular on two information-theory-based approaches (maximization of stimulus energy or of noise entropy) and a likelihood-based approach (Bayesian spike-triggered covariance, extensions of generalized linear models). We analyze the formal connection between the likelihood-based and information-based approaches to show how they lead to consistent inference. We demonstrate the practical feasibility of these procedures by using model neurons responding to a flickering variance stimulus.

Full work available at URL: https://arxiv.org/abs/1209.0121

Recommendations

• Analyzing Neural Responses to Natural Signals: Maximally Informative Dimensions
• On the Analysis and Interpretation of Inhomogeneous Quadratic Forms as Receptive Fields
• Spike-triggered covariance: geometric proof, symmetry properties, and extension beyond Gaussian stimuli
• scientific article; zbMATH DE number 1750016
• A Two-Layer Model of Natural Stimuli Estimated with Score Matching

Mathematics Subject Classification ID

General biostatistics (92B15) Neural biology (92C20)

Cites Work

• Information Theory and Statistical Mechanics
• Title not available (Why is that?)
• Spiking Neuron Models
• Title not available (Why is that?)
• Analyzing Neural Responses to Natural Signals: Maximally Informative Dimensions
• Title not available (Why is that?)
• Maximum Likelihood Estimation of a Stochastic Integrate-and-Fire Neural Encoding Model
• Nonlinear analysis with an arbitrary stimulus ensemble
• Two Computational Regimes of a Single-Compartment Neuron Separated by a Planar Boundary in Conductance Space
• Computation in a Single Neuron: Hodgkin and Huxley Revisited
• What Causes a Neuron to Spike?
• Single Neuron Computation: From Dynamical System to Feature Detector
• Maximum-entropy approximations of stochastic nonlinear transductions: An extension of the Wiener theory
• Identification of nonlinear systems by use of nonstationary white-noise inputs

Cited In (6)

• Capturing the Dynamical Repertoire of Single Neurons with Generalized Linear Models
• Scalable Variational Inference for Low-Rank Spatiotemporal Receptive Fields
• On the Analysis and Interpretation of Inhomogeneous Quadratic Forms as Receptive Fields
• Learning quantitative sequence-function relationships from massively parallel experiments
• Parametric Inference in the Large Data Limit Using Maximally Informative Models
• Designing Patient-Specific Optimal Neurostimulation Patterns for Seizure Suppression

This page was built for publication: Learning quadratic receptive fields from neural responses to natural stimuli

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5378221)