Learning quadratic receptive fields from neural responses to natural stimuli
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Publication:5378221
Abstract: Models of neural responses to stimuli with complex spatiotemporal correlation structure often assume that neurons are only selective for a small number of linear projections of a potentially high-dimensional input. Here we explore recent modeling approaches where the neural response depends on the quadratic form of the input rather than on its linear projection, that is, the neuron is sensitive to the local covariance structure of the signal preceding the spike. To infer this quadratic dependence in the presence of arbitrary (e.g. naturalistic) stimulus distribution, we review several inference methods, focussing in particular on two information-theory-based approaches (maximization of stimulus energy or of noise entropy) and a likelihood-based approach (Bayesian spike-triggered covariance, extensions of generalized linear models). We analyze the formal connection between the likelihood-based and information-based approaches to show how they lead to consistent inference. We demonstrate the practical feasibility of these procedures by using model neurons responding to a flickering variance stimulus.
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Cited in
(7)- Parametric inference in the large data limit using maximally informative models
- Learning quantitative sequence-function relationships from massively parallel experiments
- Capturing the Dynamical Repertoire of Single Neurons with Generalized Linear Models
- Spike-triggered covariance: geometric proof, symmetry properties, and extension beyond Gaussian stimuli
- Scalable Variational Inference for Low-Rank Spatiotemporal Receptive Fields
- On the Analysis and Interpretation of Inhomogeneous Quadratic Forms as Receptive Fields
- Designing patient-specific optimal neurostimulation patterns for seizure suppression
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