Decorrelation by recurrent inhibition in heterogeneous neural circuits

DOI10.1162/NECO_A_00451zbMATH Open1415.92011arXiv1107.3111WikidataQ33801640 ScholiaQ33801640MaRDI QIDQ5378226FDOQ5378226

Authors: Alberto Bernacchia, Xiaojing Wang 

Publication date: 12 June 2019

Published in: Neural Computation (Search for Journal in Brave)

Abstract: The activity of neurons is correlated, and this correlation affects how the brain processes information. We study the neural circuit mechanisms of correlations by analyzing a network model characterized by strong and heterogeneous interactions: excitatory input drives the fluctuations of neural activity, which are counterbalanced by inhibitory feedback. In particular, excitatory input tends to correlate neurons, while inhibitory feedback reduces correlations. We demonstrate that heterogeneity of synaptic connections is necessary for this inhibition of correlations. We calculate statistical averages over the disordered synaptic interactions, and we apply our findings to both a simple linear model and to a more realistic spiking network model. We find that correlations at zero time-lag are positive and of magnitude K^{-1/2}, where K is the number of connections to a neuron. Correlations at longer timescales are of smaller magnitude, of order K^{-1}, implying that inhibition of correlations occurs quickly, on a timescale of K^{-1/2}. The small magnitude of correlations agrees qualitatively with physiological measurements in the Cerebral Cortex and Basal Ganglia. The model could be used to study correlations in brain regions dominated by recurrent inhibition, such as the Striatum and Globus Pallidus.

Full work available at URL: https://arxiv.org/abs/1107.3111

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zbMATH Keywords

decorrelation by recurrent inhibitionheterogeneity of synaptic connectionsheterogeneous neural circuits

Mathematics Subject Classification ID

Neural biology (92C20) Neural networks for/in biological studies, artificial life and related topics (92B20)

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Cited In (4)

• Title not available (Why is that?)
• Investigating the correlation-firing rate relationship in heterogeneous recurrent networks
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• Correlations and Population Dynamics in Cortical Networks

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