An evolutionary reduction principle for mutation rates at multiple loci

DOI10.1007/S11538-010-9557-9zbMATH Open1215.92044arXiv0909.2454OpenAlexW1974336942WikidataQ34133036 ScholiaQ34133036MaRDI QIDQ545633FDOQ545633

Authors: Lee Altenberg 

Publication date: 22 June 2011

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event models. A multivariate form of the reduction principle is found: reduction results at individual loci combine topologically to produce a surface of mutation rate alterations that are neutral for a new modifier allele. New mutation rates survive if and only if they fall below this surface - a generalization of the hyperplane found by Zhivotovsky et al. (1994) for a multilocus recombination modifier. Increases in mutation rates at some loci may evolve if compensated for by decreases at other loci. The strength of selection on the modifier scales in proportion to the number of germline cell divisions, and increases with the number of loci affected. Loci that do not make a difference to marginal fitnesses at equilibrium are not subject to the reduction principle, and under fine tuning of mutation rates would be expected to have higher mutation rates than loci in mutation-selection balance. Other results include the nonexistence of 'viability analogous, Hardy-Weinberg' modifier polymorphisms under multiplicative mutation, and the sufficiency of average transmission rates to encapsulate the effect of modifier polymorphisms on the transmission of loci under selection. A conjecture is offered regarding situations, like recombination in the presence of mutation, that exhibit departures from the reduction principle. Constraints for tractability are: tight linkage of all loci, initial fixation at the modifier locus, and mutation distributions comprising transition probabilities of reversible Markov chains.

Full work available at URL: https://arxiv.org/abs/0909.2454

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zbMATH Keywords

spectral analysisreversible Markov chainKarlin's theoremmodifier genereduction principle

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Problems related to evolution (92D15) Stochastic matrices (15B51)

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Cited In (11)

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• Mutating away from your enemies: the evolution of mutation rate in a host-parasite system
• Modifiers of mutation rate: A general reduction principle
• Evolution of transmission modifiers under frequency-dependent selection and transmission in constant or fluctuating environments
• Evolution of reduced mutation under frequency-dependent selection
• The gossip paradox: why do bacteria share genes?
• An evolutionary reduction principle for genetic modifiers.

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