Bayesian analysis of case control polygenic etiology studies with missing data

DOI10.1093/BIOSTATISTICS/2.3.309MaRDI QIDQ5701263zbMATH OpenOpenAlexWikidataFDO

Authors David A. Schoenfeld, Xiaolin Wang, Alfred Penfornis, Denise Faustman, Mei-Ling Ting Lee

Publication date 2 November 2005

Published in Biostatistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1093/biostatistics/2.3.309

zbMATH Keywords

Dirichlet distributionGibbs samplingMissing dataConvergenceContingency tableGeneticsCase controlMultiple loci.

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Biochemistry, molecular biology (92C40) Genetics and epigenetics (92D10)

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(4)

• Bayesian epistasis association mapping via SNP imputation
• A general framework for studying genetic effects and gene-environment interactions with missing data
• Bayes factor based on a maximum statistic for case-control genetic association studies
• Block-based Bayesian epistasis association mapping with application to WTCCC type 1 diabetes data

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