Immune system - tumour efficiency ratio as a new oncological index for radiotherapy treatment optimization

DOI10.1093/IMAMMB/DQP005zbMATH Open1178.92035arXiv0706.0418OpenAlexW2117157957WikidataQ51814035 ScholiaQ51814035MaRDI QIDQ5850835FDOQ5850835

Authors: O. Sotolongo-Grau, Daniel Rodríguez-Pérez, J. A. Santos-Miranda, J. C. Antoranz, O. Sotolongo-Costa 

Publication date: 19 January 2010

Published in: Mathematical Medicine and Biology (Search for Journal in Brave)

Abstract: A dynamical system model for tumor -- immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. A characteristic parameter, the Immune System -- Tumor Efficiency Rate (ISTER), is introduced. ISTER dependence of treatment success and other features is studied. Statistical results allow us to give a patient classification scheme. Radiotherapy treatment biological effective dose (BED) is thus optimized based on the patient physical condition, following the ALARA (As Low As Reasonably Achievable) criterion.

Full work available at URL: https://arxiv.org/abs/0706.0418

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zbMATH Keywords

optimizationsimulationmodelingradiotherapy

Mathematics Subject Classification ID

Numerical optimization and variational techniques (65K10) Medical applications (general) (92C50) Qualitative investigation and simulation of ordinary differential equation models (34C60) Probabilistic models, generic numerical methods in probability and statistics (65C20)

Cited In (2)

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• A minimal modeling framework of radiation and immune system synergy to assist radiotherapy planning

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