Immune system - tumour efficiency ratio as a new oncological index for radiotherapy treatment optimization

DOI10.1093/IMAMMB/DQP005MaRDI QIDQ5850835zbMATH OpenOpenAlexWikidataFDO

Authors O. Sotolongo-Grau, Daniel Rodríguez-Pérez, J. A. Santos-Miranda, J. C. Antoranz, O. Sotolongo-Costa

Publication date 19 January 2010

Published in Mathematical Medicine and Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0706.0418

zbMATH Keywords

optimizationsimulationmodelingradiotherapy

Mathematics Subject Classification ID

Numerical optimization and variational techniques (65K10) Medical applications (general) (92C50) Qualitative investigation and simulation of ordinary differential equation models (34C60) Probabilistic models, generic numerical methods in probability and statistics (65C20)

Abstract: A dynamical system model for tumor -- immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. A characteristic parameter, the Immune System -- Tumor Efficiency Rate (ISTER), is introduced. ISTER dependence of treatment success and other features is studied. Statistical results allow us to give a patient classification scheme. Radiotherapy treatment biological effective dose (BED) is thus optimized based on the patient physical condition, following the ALARA (As Low As Reasonably Achievable) criterion.

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