Canards underlie both electrical and Ca^2+-induced early afterdepolarizations in a model for cardiac myocytes

DOI10.1137/22M147757XMaRDI QIDQ5864059zbMATH OpenFDO

Authors Joshua Kimrey, Theodore Vo, Richard Bertram

Publication date 3 June 2022

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1137/22M147757X

zbMATH Keywords

canardscardiacearly afterdepolarizationsexcitable mediamixed-mode oscillationsnumerical continuation

Mathematics Subject Classification ID

Canard solutions to ordinary differential equations (34E17) Dynamical systems in biology (37N25) General biology and biomathematics (92B05)

Recommendations

• Big ducks in the heart: canard analysis can explain large early afterdepolarizations in cardiomyocytes
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• CAN ENDOGENOUS, NOISE-TRIGGERED EARLY AFTER-DEPOLARIZATIONS INITIATE REENTRY IN A MODIFIED LUO–RUDY VENTRICULAR VIRTUAL TISSUE?
• Role of CaMKII and PKA in early afterdepolarization of human ventricular myocardium cell: a computational model study

Cites work

• Apropos canards
• Big ducks in the heart: canard analysis can explain large early afterdepolarizations in cardiomyocytes
• Canards in \(\mathbb{R}^3\)
• Existence and Bifurcation of Canards in \mathbbR^3 in the Case of a Folded Node
• Extending geometric singular perturbation theory to nonhyperbolic points -- fold and canard points in two dimensions
• Geometric singular perturbation theory for ordinary differential equations
• Giant squid-hidden canard: the 3D geometry of the Hodgkin-Huxley model
• scientific article; zbMATH DE number 799793 (Why is no real title available?)
• Mixed mode oscillations due to the generalized canard
• Multi-timescale systems and fast-slow analysis
• Saddle slow manifolds and canard orbits in \(\mathbb{R}^{4}\) and application to the full Hodgkin-Huxley model
• The Geometry of Slow Manifolds near a Folded Node
• Understanding anomalous delays in a model of intracellular calcium dynamics

Cited in

(10)

• Role of CaMKII and PKA in early afterdepolarization of human ventricular myocardium cell: a computational model study
• Stochastic mixed-mode oscillations in the canards region of a cardiac action potential model
• DAD characterization in electromechanical cardiac models
• CAN ENDOGENOUS, NOISE-TRIGGERED EARLY AFTER-DEPOLARIZATIONS INITIATE REENTRY IN A MODIFIED LUO–RUDY VENTRICULAR VIRTUAL TISSUE?
• A SIMPLE MODEL FOR INTERACTION OF VOLTAGE AND CALCIUM DYNAMICS IN VIRTUAL VENTRICULAR TISSUE
• Big ducks in the heart: canard analysis can explain large early afterdepolarizations in cardiomyocytes
• Bifurcation analysis on a generation of early afterdepolarization in a mathematical cardiac model
• Mathematical birth of early afterdepolarizations in a cardiomyocyte model
• Strong Symmetry Breaking in Coupled, Identical Lengyel–Epstein Oscillators via Folded Singularities
• Symmetry-breaking rhythms in coupled, identical fast-slow oscillators

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