Stationarity and Inference in Multistate Promoter Models of Stochastic Gene Expression via Stick-Breaking Measures

DOI10.1137/21M1440876MaRDI QIDQ5870381zbMATH OpenFDO

Authors William Lippitt, Sunder Sethuraman, Xueying Tang

Publication date 9 January 2023

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2108.10896

zbMATH Keywords

BayesianconstructiveDirichletinferenceMarkovianmodel validationmRNAmultistatepromoterproteinstationary distributionstick-breaking

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40)

Abstract: In a general stochastic multistate promoter model of dynamic mRNA/protein interactions, we identify the stationary joint distribution of the promoter state, mRNA, and protein levels through an explicit `stick-breaking' construction of interest in itself. This derivation is a constructive advance over previous work where the stationary distribution is solved only in restricted cases. Moreover, the stick-breaking construction allows to sample directly from the stationary distribution, permitting inference procedures and model selection. In this context, we discuss numerical Bayesian experiments to illustrate the results.

Recommendations

• Stochastic gene expression with a multistate promoter: breaking down exact distributions
• Analytical results for a multistate gene model
• Multimodality and flexibility of stochastic gene expression
• Statistical inference for DNA sequences of promoters: a non-stationary qualitative model
• Time-dependent propagators for stochastic models of gene expression: an analytical method

Cites work

• Analytical results for a multistate gene model
• Bayesian nonparametric data analysis
• Estimating the dimension of a model
• Fluctuations of the empirical measure of freezing Markov chains
• Fundamentals of nonparametric Bayesian inference
• scientific article; zbMATH DE number 3901778 (Why is no real title available?)
• scientific article; zbMATH DE number 1350773 (Why is no real title available?)
• Inference from iterative simulation using multiple sequences
• Markovian modelling of gene product synthesis
• Monte Carlo sampling methods using Markov chains and their applications
• Multimodality and flexibility of stochastic gene expression
• Occupation laws for some time-nonhomogeneous Markov chains
• On the \(f\)-norm ergodicity of Markov processes in continuous time
• On the use of Markovian stick-breaking priors
• Sampling-Based Approaches to Calculating Marginal Densities
• Stochastic gene expression with a multistate promoter: breaking down exact distributions
• The Poisson representation. I: A new technique for chemical master equations

Cited in

(3)

• Multimodality and flexibility of stochastic gene expression
• Stochastic gene expression with a multistate promoter: breaking down exact distributions
• Statistical inference for DNA sequences of promoters: a non-stationary qualitative model

Describes a project that uses

Uses Software

• BayesDA

This page was built for publication: Stationarity and Inference in Multistate Promoter Models of Stochastic Gene Expression via Stick-Breaking Measures

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5870381)