On an extended interpretation of linkage disequilibrium in genetic case-control association studies

DOI10.1515/SAGMB-2015-0024MaRDI QIDQ5962700zbMATH OpenOpenAlexWikidataFDO

Authors Thorsten Dickhaus, Jens Stange, Haydar Demirhan

Publication date 16 February 2016

Published in Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1515/sagmb-2015-0024

zbMATH Keywords

contingency tableFisher's exact testodds ratiocorrelation structureCochran-Armitage trend testchi-squared statisticDelta methodasymptotic Gaussianity

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) General biostatistics (92B15) Genetics and epigenetics (92D10)

Recommendations

• Tests in a Case–control Design Including Relatives
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• Multipoint linkage detection in the presence of heterogeneity

Cites work

• scientific article; zbMATH DE number 1817585 (Why is no real title available?)
• scientific article; zbMATH DE number 5604036 (Why is no real title available?)
• A statistical approach to genetic epidemiology. Concepts and application. With a foreword by Robert C. Elston.
• Inferences about Linkage Disequilibrium
• On the Exact Covariance of Products of Random Variables
• Simultaneous Statistical Inference

Cited in

(7)

• Exploring case-control genetic association tests using phase diagrams
• Multiplicity- and dependency-adjusted \(p\)-values for control of the family-wise error rate
• Unified Analysis of Secondary Traits in Case–Control Association Studies
• New perspective on the benefits of the gene–environment independence in case–control studies
• Randomized ‐values for multiple testing and their application in replicability analysis
• Case-Control Inference of Interaction between Genetic and Nongenetic Risk Factors under Assumptions on Their Distribution
• Joint consideration of multiple loci and their influence on a disease in case-control studies

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