An age-of-infection model with both symptomatic and asymptomatic infections

DOI10.1007/S00285-023-01920-WMaRDI QIDQ6038685zbMATH OpenOpenAlexFDO

Authors Fan Bai

Publication date 2 May 2023

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2111.02343

zbMATH Keywords

integro-differential equationsmathematical epidemiologyage of infection modelsdeterministic compartmental modelsfinal epidemic size estimation

Mathematics Subject Classification ID

Epidemiology (92D30) Integro-ordinary differential equations (45J05)

Abstract: We formulate a general age-of-infection epidemic model with two pathways: the symptomatic infections and the asymptomatic infections. We then calculate the basic reproduction number $mathcal{R}_0$ and establish the final size relation. It is shown that the ratio of accumulated counts of symptomatic patients and asymptomatic patients is determined by the symptomatic ratio $f$ which is defined as the probability of eventually becoming symptomatic after being infected. We also formulate and study a general age-of-infection model with disease deaths and with two infection pathways. The final size relation is investigated, and the upper and lower bounds for final epidemic size are given. Several numerical simulations are performed to verify the analytical results.

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Cited in

(6)

• Age-of-infection and the final size relation
• The state-reproduction number for a multistate class age structured epidemic system and its application to the asymptomatic transmission model
• Reproduction number for an age of infection structured model
• Who is the infector? Epidemic models with symptomatic and asymptomatic cases
• Mathematical modelling the age dependence of Epstein-Barr virus associated infectious mononucleosis
• Final size for epidemic models with asymptomatic transmission

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