Genetic Underpinnings of Brain Structural Connectome for Young Adults

DOI10.1080/01621459.2022.2156349MaRDI QIDQ6077532zbMATH OpenFDO

Authors Yize Zhao, Changgee Chang, Jingwen Zhang, Zhengwu Zhang

Publication date 18 October 2023

Published in Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2212.00967

zbMATH Keywords

Bayesian shrinkagebrain connectivityexpectation-maximizationimaging geneticsnetwork response

Mathematics Subject Classification ID

Statistics (62-XX)

Abstract: With distinct advantages in power over behavioral phenotypes, brain imaging traits have become emerging endophenotypes to dissect molecular contributions to behaviors and neuropsychiatric illnesses. Among different imaging features, brain structural connectivity (i.e., structural connectome), which summarizes the anatomical connections between different brain regions, is one of the most cutting-edge while under-investigated traits; and the genetic influence on the structural connectome variation remains highly elusive. Relying on a landmark imaging genetics study for young adults, we develop a biologically plausible brain network response shrinkage model to comprehensively characterize the relationship between high dimensional genetic variants and the structural connectome phenotype. Under a unified Bayesian framework, we accommodate the topology of brain network and biological architecture within the genome; and eventually establish a mechanistic mapping between genetic biomarkers and the associated brain sub-network units. An efficient expectation-maximization algorithm is developed to estimate the model and ensure computing feasibility. In the application to the Human Connectome Project Young Adult (HCP-YA) data, we establish the genetic underpinnings which are highly interpretable under functional annotation and brain tissue eQTL analysis, for the brain white matter tracts connecting the hippocampus and two cerebral hemispheres. We also show the superiority of our method in extensive simulations.

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Cited in

(3)

• Bayesian pathway analysis over brain network mediators for survival data
• Bayesian longitudinal network regression with application to brain connectome genetics
• Multifaceted neuroimaging data integration via analysis of subspaces

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