Identifying Effects of Multiple Treatments in the Presence of Unmeasured Confounding
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Publication:6077586
Abstract: Identification of treatment effects in the presence of unmeasured confounding is a persistent problem in the social, biological, and medical sciences. The problem of unmeasured confounding in settings with multiple treatments is most common in statistical genetics and bioinformatics settings, where researchers have developed many successful statistical strategies without engaging deeply with the causal aspects of the problem. Recently there have been a number of attempts to bridge the gap between these statistical approaches and causal inference, but these attempts have either been shown to be flawed or have relied on fully parametric assumptions. In this paper, we propose two strategies for identifying and estimating causal effects of multiple treatments in the presence of unmeasured confounding. The auxiliary variables approach leverages variables that are not causally associated with the outcome; in the case of a univariate confounder, our method only requires one auxiliary variable, unlike existing instrumental variable methods that would require as many instruments as there are treatments. An alternative null treatments approach relies on the assumption that at least half of the confounded treatments have no causal effect on the outcome, but does not require a priori knowledge of which treatments are null. Our identification strategies do not impose parametric assumptions on the outcome model and do not rest on estimation of the confounder. This paper extends and generalizes existing work on unmeasured confounding with a single treatment and models commonly used in bioinformatics.
Cites work
- A factor model approach to multiple testing under dependence
- A lava attack on the recovery of sums of dense and sparse signals
- A new approach to causal inference in mortality studies with a sustained exposure period—application to control of the healthy worker survivor effect
- A new instrumental method for dealing with endogenous selection
- ACE bounds; SEMs with equilibrium conditions
- An IV Model of Quantile Treatment Effects
- Batch effects correction with unknown subtypes
- Bi-cross-validation for factor analysis
- Bounded, efficient and multiply robust estimation of average treatment effects using instrumental variables
- Bounds on Treatment Effects From Studies With Imperfect Compliance
- Causal diagrams for empirical research
- Comment on “Blessings of Multiple Causes”
- Comment on: “The Blessings of Multiple Causes” by Yixin Wang and David M. Blei
- Comment: Reflections on the Deconfounder
- Comment: The challenges of multiple causes
- Confounder adjustment in multiple hypothesis testing
- Doubly debiased Lasso: high-dimensional inference under hidden confounding
- Doubly robust estimation of the local average treatment effect curve
- Examples of \(L^2\)-complete and boundedly-complete distributions
- Generalized Cornfield conditions for the risk difference
- scientific article; zbMATH DE number 3117083 (Why is no real title available?)
- Identifiability of causal effects with multiple causes and a binary outcome
- Identification and estimation of triangular simultaneous equations models without additivity
- Identification and inference with nonignorable missing covariate data
- Identification of Causal Effects Using Instrumental Variables
- Identifying causal effects with proxy variables of an unmeasured confounder
- Inference on the order of a normal mixture
- Instrumental Variable Estimation of Nonparametric Models
- Instrumental variable estimation with a stochastic monotonicity assumption
- Instrumental Variable Treatment of Nonclassical Measurement Error Models
- Linear integral equations
- Local identification of nonparametric and semiparametric models
- Measurement bias and effect restoration in causal inference
- Mendelian randomization as an instrumental variable approach to causal inference
- Multiply Robust Causal Inference with Double-Negative Control Adjustment for Categorical Unmeasured Confounding
- On an algorithm for solving Fredholm integrals of the first kind
- On the completeness condition in nonparametric instrumental problems
- On the Identifiability of Finite Mixtures
- On the testability of identification in some nonparametric models with endogeneity
- On varieties of doubly robust estimators under missingness not at random with a shadow variable
- Principles of applied statistics
- Regularization methods for high-dimensional instrumental variables regression with an application to genetical genomics
- Spectral deconfounding via perturbed sparse linear models
- Statistical analysis of finite mixture distributions
- The blessings of multiple causes
Cited in
(14)- The identification of direct and indirect effects in studies with an unmeasured intermediate variable
- Identification and efficient estimation of the natural direct effect among the untreated
- Identification of causal effects with latent confounding and classical additive errors in treatment
- Identifying Treatment Effects Under Data Combination
- An introduction to proximal causal inference
- A self-censoring model for multivariate nonignorable nonmonotone missing data
- Simultaneous Estimation of Multiple Treatment Effects from Observational Studies
- Sensitivity analysis for effects of multiple exposures in the presence of unmeasured confounding: non-Gaussian and time-to-event outcomes
- Mediation analysis with unmeasured confounding between parallel mediators and outcome
- Discussion on: ``Causal and counterfactual views of missing data models
- Assumption-lean post-integrated inference with surrogate-control outcomes
- Identifiability and estimation of causal effects with non-Gaussianity and auxiliary covariates
- A Bayesian approach to estimate causal peer influence accounting for latent network homophily
- The synthetic instrument: from sparse association to sparse causation
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