A coupled stochastic differential reaction-diffusion system for angiogenesis

DOI10.1016/J.CAM.2023.115570MaRDI QIDQ6079939zbMATH OpenOpenAlexFDO

Authors Markus Fellner, Ansgar Jüngel

Publication date 30 October 2023

Published in Journal of Computational and Applied Mathematics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2206.11510

zbMATH Keywords

angiogenesisreaction-diffusion equationsstochastic differential equationsexistence analysistip cell movement

Mathematics Subject Classification ID

Ordinary differential equations and systems with randomness (34F05) Reaction-diffusion equations (35K57) PDEs with randomness, stochastic partial differential equations (35R60) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

Abstract: A coupled system of nonlinear mixed-type equations modeling early stages of angiogenesis is analyzed in a bounded domain. The system consists of stochastic differential equations describing the movement of the positions of the tip and stalk endothelial cells, due to chemotaxis, durotaxis, and random motion; ordinary differential equations for the volume fractions of the extracellular fluid, basement membrane, and fibrin matrix; and reaction-diffusion equations for the concentrations of several proteins involved in the angiogenesis process. The drift terms of the stochastic differential equations involve the gradients of the volume fractions and the concentrations, and the diffusivities in the reaction-diffusion equations depend nonlocally on the volume fractions, making the system highly nonlinear. The existence of a unique solution to this system is proved by using fixed-point arguments and H"older regularity theory. Numerical experiments in two space dimensions illustrate the onset of formation of vessels.

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