Slow-fast dynamics in a neurotransmitter release model: delayed response to a time-dependent input signal

DOI10.1016/J.PHYSD.2023.133887zbMATH Open1527.34084arXiv2302.12852OpenAlexW4385753505MaRDI QIDQ6090635FDOQ6090635

Authors: Mattia Sensi, Mathieu Desroches, S. Rodrigues 

Publication date: 17 November 2023

Published in: Physica D (Search for Journal in Brave)

Abstract: We propose a generalization of the neurotransmitter release model proposed in emph{Rodrigues et al. (PNAS, 2016)}. We increase the complexity of the underlying slow-fast system by considering a degree-four polynomial as parametrization of the critical manifold. We focus on the possible transient and asymptotic dynamics, exploiting the so-called entry-exit function to describe slow parts of the dynamics. We provide extensive numerical simulations, complemented by numerical bifurcation analysis.

Full work available at URL: https://arxiv.org/abs/2302.12852

zbMATH Keywords

canardsslow-fast systembifurcation analysisentry-exit functionvesicle cycle

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Neural biology (92C20) Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Bifurcation theory for ordinary differential equations (34C23) Invariant manifolds for ordinary differential equations (34C45) Stability of solutions to ordinary differential equations (34D20) Singular perturbations for ordinary differential equations (34E15) Canard solutions to ordinary differential equations (34E17)

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Cited In (2)

• On the feedback between theory and experiment in elucidating the molecular mechanisms underlying neurotransmitter release
• Theory for the feedback inhibition of fast release of neurotransmitter

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