Combining biomarkers by maximizing the true positive rate for a fixed false positive rate

DOI10.1002/BIMJ.202000210MaRDI QIDQ6091667zbMATH OpenOpenAlexFDO

Authors Marco Carone, M. Pepe

Publication date 27 November 2023

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1910.02087, https://biostats.bepress.com/uwbiostat/paper420

zbMATH Keywords

biomarker combinationsfalse positive ratesensitivityspecificitytrue positive rate

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: Biomarkers abound in many areas of clinical research, and often investigators are interested in combining them for diagnosis, prognosis, or screening. In many applications, the true positive rate for a biomarker combination at a prespecified, clinically acceptable false positive rate is the most relevant measure of predictive capacity. We propose a distribution-free method for constructing biomarker combinations by maximizing the true positive rate while constraining the false positive rate. Theoretical results demonstrate desirable properties of biomarker combinations produced by the new method. In simulations, the biomarker combination provided by our method demonstrated improved operating characteristics in a variety of scenarios when compared with alternative methods for constructing biomarker combinations.

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Cited in

(3)

• Combining binary and continuous biomarkers by maximizing the area under the receiver operating characteristic curve
• Conditional concordance-assisted learning under matched case-control design for combining biomarkers for population screening
• Linear biomarker combination for constrained classification

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