Astrocytic clearance and fragmentation of toxic proteins in Alzheimer's disease on large-scale brain networks

DOI10.1016/J.PHYSD.2023.133839MaRDI QIDQ6096522zbMATH OpenFDO

Authors Hina Shaheen, Swadesh Pal, R. V. N. Melnik

Publication date 12 September 2023

Published in Physica D (Search for Journal in Brave)

zbMATH Keywords

Alzheimer's diseasemultiscale modellinglarge-scale brain networksnonlinear Smoluchowski equation

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Neural networks for/in biological studies, artificial life and related topics (92B20) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Pathology, pathophysiology (92C32)

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Cites work

• Alzheimer's disease: a mathematical model for onset and progression
• An introduction to mathematical models of coagulation--fragmentation processes: a discrete deterministic mean-field approach
• Mathematical analysis for stochastic model of Alzheimer's disease
• Some modelling issues in the theory of fragmentation-coagulation systems
• Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome

Cited in

(6)

• The role of clearance in neurodegenerative diseases
• Image-guided subject-specific modeling of glymphatic transport and amyloid deposition
• Aggregation of microglia in 2D with string gradient weighted moving finite elements
• Discovering a reaction-diffusion model for Alzheimer's disease by combining PINNs with symbolic regression
• A network thermodynamic analysis of amyloid aggregation along competing pathways
• Modeling neurodegeneration in chronic traumatic encephalopathy using gradient damage models

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