Mathematical analysis of a kinetic model for cell movement in network tissues

DOI10.3934/DCDSB.2010.14.1055MaRDI QIDQ612892zbMATHOpenAlexFDO

Authors Thomas Hillen, Peter Hinow, Zhi-An Wang

Publication date 16 December 2010

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0807.2249

zbMATH Keywords

global existencemild and classical solutionsparabolic limitspatterns of network typepointwise steady states

Mathematics Subject Classification ID

Initial value problems for first-order hyperbolic systems (35L45) First-order nonlinear hyperbolic equations (35L60) Cell movement (chemotaxis, etc.) (92C17) Abstract hyperbolic equations (35L90)

Abstract: Mesenchymal motion describes the movement of cells in biological tissues formed by fiber networks. An important example is the migration of tumor cells through collagen networks during the process of metastasis formation. We investigate the mesenchymal motion model proposed by T. Hillen (J. Math. Biol. 53:585-616, 2006) in higher dimensions. We formulate the problem as an evolution equation in a Banach space of measure-valued functions and use methods from semigroup theory to show the global existence of classical solutions. We investigate steady states of the model and show that patterns of network type exist as steady states. For the case of constant fiber distribution, we find an explicit solution and we prove the convergence to the parabolic limit.

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