Simple mechanical cues could explain adipose tissue morphology

DOI10.1016/J.JTBI.2017.06.030zbMATH Open1382.92027arXiv1703.04729OpenAlexW2596223214WikidataQ47787275 ScholiaQ47787275MaRDI QIDQ1704321FDOQ1704321

Authors: Diane Peurichard, C. Barreau, J. Rouquette, Pierre Degond, Fanny Delebecque, Anne Lorsignol, Xavier Descombes, Louis Casteilla 

Publication date: 9 March 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: The mechanisms by which organs acquire their functional structure and realize its maintenance (or homeostasis) over time are still largely unknown. In this paper, we investigate this question on adipose tissue. Adipose tissue can represent 20 to 50% of the body weight. Its investigation is key to overcome a large array of metabolic disorders that heavily strike populations worldwide. Adipose tissue consists of lobular clusters of adipocytes surrounded by an organized collagen fiber network. By supplying substrates needed for adipogenesis, vasculature was believed to induce the regroupment of adipocytes near capillary extremities. This paper shows that the emergence of these structures could be explained by simple mechanical interactions between the adipocytes and the collagen fibers. Our assumption is that the fiber network resists the pressure induced by the growing adipocytes and forces them to regroup into clusters. Reciprocally, cell clusters force the fibers to merge into a well-organized network. We validate this hypothesis by means of a two-dimensional Individual Based Model (IBM) of interacting adipocytes and extra-cellular-matrix fiber elements. The model produces structures that compare quantitatively well to the experimental observations. Our model seems to indicate that cell clusters could spontaneously emerge as a result of simple mechanical interactions between cells and fibers and surprisingly, vasculature is not directly needed for these structures to emerge.

Full work available at URL: https://arxiv.org/abs/1703.04729

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zbMATH Keywords

image segmentationadipose tissuemathematical modelingmorphogenesisagent-based modellobule-like structure

Mathematics Subject Classification ID

Biomechanics (92C10) Developmental biology, pattern formation (92C15) Cell biology (92C37)

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Cited In (10)

• Modelling pattern formation through differential repulsion
• A Lifshitz-Slyozov type model for adipocyte size dynamics: limit from Becker-Döring system and numerical simulation
• Extra-cellular matrix rigidity may dictate the fate of injury outcome
• On the complexity of barrier resilience for fat regions
• Continuum model for linked fibers with alignment interactions
• Fast Non-mean-field Networks: Uniform in Time Averaging
• Are tumor cell lineages solely shaped by mechanical forces?
• A micromechanical model for the Young's modulus of adipose tissue
• Macroscopic Model for Cross-Linked Fibers with Alignment Interactions: Existence Theory and Numerical Simulations
• A new model for the emergence of blood capillary networks

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