A chemotaxis reaction-diffusion model for multiple sclerosis with Allee effect
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Publication:6131669
DOI10.1007/S11587-023-00806-9arXiv2303.01764OpenAlexW4385579275MaRDI QIDQ6131669FDOQ6131669
M. Bisi, G. Martalò, Maria Groppi, C. Soresina
Publication date: 18 April 2024
Published in: Ricerche di Matematica (Search for Journal in Brave)
Abstract: In this paper, we study a modification of the mathematical model describing inflammation and demyelination patterns in the brain caused by Multiple Sclerosis proposed in [Lombardo et al. (2017), Journal of Mathematical Biology, 75, 373--417]. In particular, we hypothesize a minimal amount of macrophages to be able to start and sustain the inflammatory response. Thus, the model function for macrophage activation includes an Allee effect. We investigate the emergence of Turing patterns by combining linearised and weakly nonlinear analysis, bifurcation diagrams and numerical simulations, focusing on the comparison with the previous model.
Full work available at URL: https://arxiv.org/abs/2303.01764
Reaction-diffusion equations (35K57) Developmental biology, pattern formation (92C15) Cell movement (chemotaxis, etc.) (92C17) Pathology, pathophysiology (92C32)
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