A chemotaxis reaction-diffusion model for multiple sclerosis with Allee effect

DOI10.1007/S11587-023-00806-9MaRDI QIDQ6131669zbMATH OpenOpenAlexFDO

Authors M. Bisi, Maria Groppi, G. Martalò, C. Soresina

Publication date 18 April 2024

Published in Ricerche di Matematica (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2303.01764

zbMATH Keywords

Allee effectpattern formationTuring instabilityweakly nonlinear analysismultiple sclerosis

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) Developmental biology, pattern formation (92C15) Cell movement (chemotaxis, etc.) (92C17) Pathology, pathophysiology (92C32)

Abstract: In this paper, we study a modification of the mathematical model describing inflammation and demyelination patterns in the brain caused by Multiple Sclerosis proposed in [Lombardo et al. (2017), Journal of Mathematical Biology, 75, 373--417]. In particular, we hypothesize a minimal amount of macrophages to be able to start and sustain the inflammatory response. Thus, the model function for macrophage activation includes an Allee effect. We investigate the emergence of Turing patterns by combining linearised and weakly nonlinear analysis, bifurcation diagrams and numerical simulations, focusing on the comparison with the previous model.

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Cited in

(1)

• Reaction-diffusion systems derived from kinetic theory for multiple sclerosis

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