Optimal control of a reaction–diffusion model related to the spread of COVID-19

DOI10.1142/S0219530523500197MaRDI QIDQ6145799zbMATH OpenWikidataFDO

Authors Pierluigi Colli, Gianni Gilardi, Gabriela Marinoschi, Elisabetta Rocca

Publication date 9 January 2024

Published in Analysis and Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2304.11114

zbMATH Keywords

COVID-19epidemic modelsexistence of solutionsoptimal controlpartial differential equationsreaction-diffusion systemuniqueness

Mathematics Subject Classification ID

Existence problems for PDEs: global existence, local existence, non-existence (35A01) Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) Nonlinear parabolic equations (35K55) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Applications of functional analysis in biology and other sciences (46N60) Existence theories for optimal control problems involving partial differential equations (49J20) Epidemiology (92D30)

Abstract: This paper is concerned with the well-posedness and optimal control problem of a reaction-diffusion system for an epidemic Susceptible-Infected-Recovered-Susceptible (SIRS) mathematical model in which the dynamics develops in a spatially heterogeneous environment. Using as control variables the transmission rates $u_i$ and $u_e$ of contagion resulting from the contact with both asymptomatic and symptomatic persons, respectively, we optimize the number of exposed and infected individuals at a final time $T$ of the controlled evolution of the system. More precisely, we search for the optimal $u_i$ and $u_e$ such that the number of infected plus exposed does not exceed at the final time a threshold value $Lambda$, fixed a priori. We prove here the existence of optimal controls in a proper functional framework and we derive the first-order necessary optimality conditions in terms of the adjoint variables.

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Cited in

(9)

• Parameter Estimation via Adjoint Functions in Epidemiological Reaction-Diffusion Models
• A time-space integro-differential economic model of epidemic control
• Global solution and optimal control of an epidemic propagation with a heterogeneous diffusion
• Viscosity solutions to the inhomogeneous reaction-diffusion equation involving the infinity Laplacian
• Chemotaxis-inspired PDE model for airborne infectious disease transmission: analysis and simulations
• Analysis and optimal control of nonlocal age- and space-structured SVIR models
• Asymptotic analysis of the SEIR epidemic model based on the matched asymptotic method of singular perturbation theory
• Trajectory corridor design for the ascent phase of horizontal takeoff and landing spaceplanes
• Spatiotemporal dynamics and optimal control of an infection-age structured reaction-diffusion epidemic model with waning immunity

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