Effects of epistasis and the evolution of genetic architecture: exact results for a 2-locus model

DOI10.1016/J.TPB.2008.12.003MaRDI QIDQ615584zbMATH OpenOpenAlexWikidataFDO

Authors José M. Álvarez-Castro, Michael Kopp, Joachim Hermisson

Publication date 5 January 2011

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://phaidra.univie.ac.at/o:292185

zbMATH Keywords

epistasismutation-selection modelgenetic variancecanalizationgenetic architecture

Mathematics Subject Classification ID

Problems related to evolution (92D15) Probabilistic models, generic numerical methods in probability and statistics (65C20)

Recommendations

• The role of epistatic gene interactions in the response to selection and the evolution of evolvabil\-i\-ty
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Cites work

• scientific article; zbMATH DE number 1455131 (Why is no real title available?)
• Adaptive inertia caused by hidden pleiotropic effects
• Dynamics of polygenic characters under selection
• Heritable genetic variation via mutation-selection balance: Lerch's zeta meets the abdominal bristle
• Modeling genetic architecture: A multilinear theory of gene interaction
• Numerical and exact solutions for continuum of alleles models
• On the evolution of epistasis. III: The haploid case with mutation
• The role of epistatic gene interactions in the response to selection and the evolution of evolvabil\-i\-ty

Cited in

(15)

• The E(NK) model: Extending the NK model to incorporate gene-by-environment interactions and epistasis for diploid genomes
• Effects of epistasis on phenotypic robustness in metabolic pathways
• Epistasis can increase multivariate trait diversity in haploid non-recombining populations
• Additive genetic variation and evolvability of a multivariate trait can be increased by epistatic gene action
• The 2-epistasis of fitness functions
• Multilocus population-genetic theory
• On the evolution of epistasis. II: A generalized Wright-Kimura framework
• Prediction of effects of genetic drift on variance components under a general model of epistasis
• A simple model of co-evolutionary dynamics caused by epistatic selection
• Modeling genetic architecture: A multilinear theory of gene interaction
• Epistasis and the conversion of non-additive to additive genetic variance at population bottle\-necks.
• Adaptive inertia caused by hidden pleiotropic effects
• The mapping of epistatic effects onto a genealogical tree in haploid populations
• The role of epistatic gene interactions in the response to selection and the evolution of evolvabil\-i\-ty
• On the evolution of epistasis. I: Diploids under selection

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