Homogenization theory of ion transportation in multicellular tissue

DOI10.3934/DCDSB.2023072MaRDI QIDQ6156570zbMATH OpenOpenAlexFDO

Authors Chun Xiao, Huaxiong Huang, Shixin Xu, Tao Yu, Xingye Yue

Publication date 13 June 2023

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2103.06019

zbMATH Keywords

bi-domain modelconnectivityion transportunfolding operator

Mathematics Subject Classification ID

Existence problems for PDEs: global existence, local existence, non-existence (35A01) Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) Homogenization in context of PDEs; PDEs in media with periodic structure (35B27) Asymptotic behavior of solutions to PDEs (35B40) A priori estimates in context of PDEs (35B45) Smoothness and regularity of solutions to PDEs (35B65) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Motion of charged particles (78A35) Biophysics (92C05) Cell biology (92C37)

Abstract: Ion transport in biological tissues is crucial in the study of many biological and pathological problems. Some multi-cellular structures, like smooth muscles on the vessel walls, could be treated as periodic bi-domain structures, which consist of intracellular space and extracellular space with semipermeable membranes in between. With the aid of two-scale homogenization theory, macro-scale models are proposed based on an electro-neutral (EN) microscale model with nonlinear interface conditions, where membranes are treated as combinations of capacitors and resistors. The connectivity of intracellular space is also taken into consideration. If the intracellular space is fully connected and forms a syncytium, then the macroscale model is a bidomain nonlinear coupled partial differential equations system. Otherwise, when the intracellular cells are not connected, the macroscale model for intracellular space is an ordinary differential system with source/sink terms from the connected extracellular space.

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Cited in

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