Influence of telomerase activity and initial distribution on human follicular aging: moving from a discrete to a continuum model

DOI10.1016/J.MBS.2023.108985MaRDI QIDQ6157785zbMATH OpenOpenAlexFDO

Authors A. M. Portillo, E. Varela, J. A. García-Velasco

Publication date 22 June 2023

Published in Mathematical Biosciences (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1016/j.mbs.2023.108985

zbMATH Keywords

Brownian motionagingfertilitypartial differential equationstochastic processfollicleHayflick limittelomereovarytelomerase activity

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Developmental biology, pattern formation (92C15) Cell biology (92C37)

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Cites work

• Mathematical model to study the aging of the human follicle according to the telomerase activity
• Mathematical modelling of ageing acceleration of the human follicle due to oxidative stress and other factors
• Mathematical modelling of telomere length dynamics
• The convection-diffusion equation for a finite domain with time varying boundaries

Cited in

(2)

• Predicting maximum lifespan limits at mean menopausal age
• An in-silico approach to the dynamics of proliferation potential in stem cells and the study of different therapies in cases of ovarian dysfunction

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