Cross-study replicability in cluster analysis
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Publication:6166879
DOI10.1214/22-STS871arXiv2202.01910MaRDI QIDQ6166879FDOQ6166879
Authors: Lorenzo Masoero, Emma G. Thomas, Giovanni Parmigiani, Svitlana Tyekucheva, Lorenzo Trippa 
Publication date: 7 July 2023
Published in: Statistical Science (Search for Journal in Brave)
Abstract: In cancer research, clustering techniques are widely used for exploratory analyses and dimensionality reduction, playing a critical role in the identification of novel cancer subtypes, often with direct implications for patient management. As data collected by multiple research groups grows, it is increasingly feasible to investigate the replicability of clustering procedures, that is, their ability to consistently recover biologically meaningful clusters across several datasets. In this paper, we review existing methods to assess replicability of clustering analyses, and discuss a framework for evaluating cross-study clustering replicability, useful when two or more studies are available. These approaches can be applied to any clustering algorithm and can employ different measures of similarity between partitions to quantify replicability, globally (i.e. for the whole sample) as well as locally (i.e. for individual clusters). Using experiments on synthetic and real gene expression data, we illustrate the utility of replicability metrics to evaluate if the same clusters are identified consistently across a collection of datasets.
Full work available at URL: https://arxiv.org/abs/2202.01910
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