Unlabelled landmark matching via Bayesian data selection, and application to cell matching across imaging modalities

DOI10.1007/S11222-023-10259-7zbMATH Open1517.62016arXiv2205.15167MaRDI QIDQ6172162FDOQ6172162

Authors: Jessica E. Forsyth, Ali H. Al-Anbaki, Berenika Plusa, S. L. Cotter 

Publication date: 16 August 2023

Published in: Statistics and Computing (Search for Journal in Brave)

Abstract: We consider the problem of landmark matching between two unlabelled point sets, in particular where the number of points in each cloud may differ, and where points in each cloud may not have a corresponding match. We invoke a Bayesian framework to identify the transformation of coordinates that maps one cloud to the other, alongside correspondence of the points. This problem necessitates a novel methodology for Bayesian data selection; simultaneous inference of model parameters, and selection of the data which leads to the best fit of the model to the majority of the data. We apply this to a problem in developmental biology where the landmarks correspond to segmented cell centres, where potential death or division of cells can lead to discrepancies between the point-sets from each image. We validate the efficacy of our approach using in silico tests and a microinjected fluorescent marker experiment. Subsequently we apply our approach to the matching of cells between real time imaging and immunostaining experiments, facilitating the combination of single-cell data between imaging modalities. Furthermore our approach to Bayesian data selection is broadly applicable across data science, and has the potential to change the way we think about fitting models to data.

Full work available at URL: https://arxiv.org/abs/2205.15167

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zbMATH Keywords

landmark matchingBayesian data selectionmulti-modal image analysis

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited In (1)

• Bayesian matching of unlabeled marked point sets using random fields, with an application to molecular alignment

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