Abstract: In Bhattacharya et al. (Science Advances, 2020), a set of chemical reactions involved in the dynamics of actin waves in cells was studied. Both at the microscopic level, where the individual chemical reactions are directly modelled using Gillespie-type algorithms, and on a macroscopic level where a deterministic reaction-diffusion equation arises as the large-scale limit of the underlying chemical reactions. In this work, we derive, and subsequently study, the related mesoscopic stochastic reaction-diffusion system, or Chemical Langevin Equation, that arises from the same set of chemical reactions. We explain how the stochastic patterns that arise from this equation can be used to understand the experimentally observed dynamics from Bhattacharya et al. In particular, we argue that the mesoscopic stochastic model better captures the microscopic behaviour than the deterministic reaction-diffusion equation, while being more amenable for mathematical analysis and numerical simulations than the microscopic model.
The authors study the dynamics of actin waves in cells. The microscopic level where chemical reactions are described and the macroscopic level where reaction-diffusion equations are used, have been replaced by a mesoscopic description based on stochastic differential equations like chemical Langevin equation. This approach leads to better results than rough microscopic picture, and at the same time the model can be studied mathematically and via numerical simulations efficiently.
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Cites work
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- scientific article; zbMATH DE number 799793 (Why is no real title available?)
- Spatially periodic and aperiodic multi-pulse patterns in the one-dimensional Gierer-Meinhardt equation
- Stability of traveling pulses with oscillatory tails in the FitzHugh-Nagumo system
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(6)- A model for intracellular actin waves explored by nonlinear local perturbation analysis
- Stochastic models for cell motion and taxis
- Numerical simulations of stochastic differential equation model for spatiotemporal biological interactions
- Spots, stripes, and spiral waves in models for static and motile cells. GTPase patterns in cells
- Multiscale stochastic reaction-diffusion modeling: application to actin dynamics in filopodia
- Excitable dynamics in a molecularly-explicit model of cell motility: mixed-mode oscillations and beyond
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