Transfer Learning of Individualized Treatment Rules from Experimental to Real-World Data

DOI10.1080/10618600.2022.2141752arXiv2108.08415MaRDI QIDQ6180733FDOQ6180733

Authors:

Publication date: 22 January 2024

Published in: Journal of Computational and Graphical Statistics (Search for Journal in Brave)

Abstract: Individualized treatment effect lies at the heart of precision medicine. Interpretable individualized treatment rules (ITRs) are desirable for clinicians or policymakers due to their intuitive appeal and transparency. The gold-standard approach to estimating the ITRs is randomized experiments, where subjects are randomized to different treatment groups and the bias is minimized to the extent possible. However, experimental data are limited in external validity because of their selection restrictions and therefore are not representative of the target real-world population. Conventional learning methods of optimal interpretable ITRs for a target population based only on experimental data are biased. On the other hand, real-world data (RWD) are becoming popular and provide a representative sample of the population. To learn the generalizable optimal interpretable ITRs, we propose an integrative transfer learning method based on weighting schemes to calibrate the covariate distribution of the experiment to that of the RWD. We show that the proposed ITR estimator has a theoretical guarantee of the risk consistency. We evaluate the transfer learner based on the finite-sample performance through simulation and apply it to a real data application of a job training program.

Full work available at URL: https://arxiv.org/abs/2108.08415

zbMATH Keywords

augmented inverse probability weightingcross-validationcovariate shifttransportabilityclassification errorcalibration weighting

Mathematics Subject Classification ID

Statistics (62-XX)

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Cited In (3)

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• Causal inference methods for combining randomized trials and observational studies: a review

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