Pairwise and higher-order epistatic effects among somatic cancer mutations across oncogenesis

DOI10.1016/j.mbs.2023.109091OpenAlexW4388921175MaRDI QIDQ6194299

Jeffrey P. Townsend, Jorge A. Alfaro-Murillo

Publication date: 14 February 2024

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2023.109091

zbMATH Keywords

geneticsepistasisselectioncancermutationmutual exclusivityco-occurrence

Mathematics Subject Classification ID

Applications of continuous-time Markov processes on discrete state spaces (60J28) Pathology, pathophysiology (92C32)

Cites Work

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• The influence of higher-order epistasis on biological fitness landscape topography
• Mathematical Oncology: Using Mathematics to Enable Cancer Discoveries
• The Large-Sample Distribution of the Likelihood Ratio for Testing Composite Hypotheses

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