How hyperpolarization and the recovery of excitability affect propagation through a virtual anode in the heart
Summary: Researchers have suggested that the fate of a shock-induced wave front at the edge of a ``virtual anode (a region hyperpolarized by the shock) is a key factor determining success or failure during defibrillation of the heart. We use a simple one-dimensional computer model to examine propagation speed through a hyperpolarized region. Our goal is to test the hypothesis that rapid propagation through a virtual anode can cause failure of propagation at the edge of the virtual anode. The calculations support this hypothesis and suggest that the time constant of the sodium inactivation gate is an important parameter. These results may be significant in understanding the mechanism of the upper limit of vulnerability.
- How the anisotropy of the intracellular and extracellular conductivities influences stimulation of cardiac muscle
- Effect of cardiac tissue anisotropy on three-dimensional electrical action potential propagation
- scientific article; zbMATH DE number 4053409
- Exploring anodal and cathodal make and break cardiac excitation mechanisms in a 3D anisotrop\-ic bidomain model
- Influence of cardiac tissue anisotropy on re-entrant activation in computational models of ventricular fibrillation
- Vulnerability to re-entry in simulated two-dimensional cardiac tissue: Effects of electrical restitution and stimulation sequence
- Effects of transmural electrical heterogeneities and electrotonic interactions on the dispersion of cardiac repolarization and action potential duration: A simulation study
- Modeling ventricular repolarization: Effects of transmural and apex-to-base heterogeneities in action potential durations
This page was built for publication: How hyperpolarization and the recovery of excitability affect propagation through a virtual anode in the heart
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q629156)
