A hopping mechanism for cargo transport by molecular motors on crowded microtubules
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Abstract: Most models designed to study the bidirectional movement of cargos as they are driven by molecular motors rely on the idea that motors of different polarities can be coordinated by external agents if arranged into a motor-cargo complex to perform the necessary work [gross04]. Although these models have provided us with important insights into these phenomena, there are still many unanswered questions regarding the mechanisms through which the movement of the complex takes place on crowded microtubules. For example (i) how does cargo-binding affect motor motility? and in connection with that - (ii) how does the presence of other motors (and also other cargos) on the microtubule affect the motility of the motor-cargo complex? We discuss these questions from a different perspective. The movement of a cargo is conceived here as a hopping process resulting from the transference of cargo between neighboring motors. In the light of this, we examine the conditions under which cargo might display bidirectional movement even if directed by motors of a single polarity. The global properties of the model in the long-time regime are obtained by mapping the dynamics of the collection of interacting motors and cargos into an asymmetric simple exclusion process (ASEP) which can be resolved using the matrix ansatz introduced by Derrida [Derrida et al].
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- Asymptotic analysis of microtubule-based transport by multiple identical molecular motors
- Collective molecular motor transport
- Microtubule patterning in the presence of moving motor proteins
Cites work
- Asymptotic analysis. Reprint
- Exact solution of a 1D asymmetric exclusion model using a matrix formulation
- Exact solution of the totally asymmetric simple exclusion process: shock profiles
- Microscopic structure of travelling waves in the asymmetric simple exclusion process
- Nonequilibrium steady states of matrix-product form: a solver's guide
- The \(1/N\)-expansion as a perturbation about the mean field theory: A one-dimensional Fermi model
- Traffic of molecular motors through tube-like compartments
Cited in
(11)- Motility states of molecular motors engaged in a stochastic tug-of-war
- Traffic of molecular motors through tube-like compartments
- Bidirectionality from cargo thermal fluctuations in motor-mediated transport
- Asymptotic analysis of microtubule-based transport by multiple identical molecular motors
- Bidirectional sliding of two parallel microtubules generated by multiple identical motors
- Slow and fast grouping of cargo velocities in axonal transport due to single versus multi-motor transport
- Bidirectional traffic on microtubules
- Cargo transport properties are enhanced by cylindrical microtubule geometry and elliptical contact zone on cargo surface
- From the cell membrane to the nucleus: unearthing transport mechanisms for dynein
- Application of quasi-steady state methods to molecular motor transport on microtubules in fungal hyphae
- Stochastic modelling of collective motor protein transport through a crossing of microtubules
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