Mathematical analysis of a two-dimensional population model of metastatic growth including angiogenesis

DOI10.1007/S00028-010-0088-5MaRDI QIDQ657013zbMATH OpenOpenAlexFDO

Authors Benzekry Sébastien

Publication date 13 January 2012

Published in Journal of Evolution Equations (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1009.2863

zbMATH Keywords

semigrouptransport equationnonlocal boundary condition2D structured populationsMalthus parametersource term on the boundaryvanishing velocity field

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Asymptotic behavior of solutions to PDEs (35B40) Smoothness and regularity of solutions to PDEs (35B65) Existence problems for PDEs: global existence, local existence, non-existence (35A01) One-parameter semigroups and linear evolution equations (47D06) Initial-boundary value problems for nonlinear first-order PDEs (35F31)

Abstract: Angiogenesis is a key process in the tumoral growth which allows the cancerous tissue to impact on its vasculature in order to improve the nutrient's supply and the metastatic process. In this paper, we introduce a model for the density of metastasis which takes into account for this feature. It is a two dimensional structured equation with a vanishing velocity field and a source term on the boundary. We present here the mathematical analysis of the model, namely the well-posedness of the equation and the asymptotic behavior of the solutions, whose natural regularity led us to investigate some basic properties of the space $Wd(Om)=Vin{L}^1;;div(GV)in{L}^1$, where $G$ is the velocity field of the equation.

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Cited in

(9)

• Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers
• Mathematical and numerical analysis for a model of growing metastatic tumors
• A mathematical framework for modelling the metastatic spread of cancer
• Passing to the limit 2D-1D in a model for metastatic growth
• A model describing the growth and the size distribution of multiple metastatic tumors
• A mathematical model for the immune-mediated theory of metastasis
• Efficient resolution of metastatic tumor growth models by reformulation into integral equations
• ANALYSIS OF A MATHEMATICAL MODEL OF TUMOR LYMPHANGIOGENESIS
• Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers

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