A model of host response to a multi-stage pathogen

DOI10.1007/S00285-010-0365-5zbMATH Open1230.92029arXiv1005.0332OpenAlexW2032572082WikidataQ42578310 ScholiaQ42578310MaRDI QIDQ659020FDOQ659020

Authors: Juan-Miguel Gracia 

Publication date: 9 February 2012

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We model the immune surveillance of a pathogen which passes through $n$ immunologically distinct stages. The biological parameters of this system induce a partial order on the stages, and this, in turn, determines which stages will be subject to immune regulation. This corresponds to the system's unique asymptotically stable fixed point.

Full work available at URL: https://arxiv.org/abs/1005.0332

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zbMATH Keywords

immunologyHost-pathogen interactionsModels of microepidemics

Mathematics Subject Classification ID

Medical epidemiology (92C60) Partial orders, general (06A06) Qualitative investigation and simulation of ordinary differential equation models (34C60) Dynamical systems in biology (37N25)

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Cited In (5)

• An in-host model of acute infection: measles as a case study
• Etiology of IRF models
• Synergy of local, regional, and systemic non-specific stressors for host defense against pathogens
• Marchuk's models of infection diseases: new developments
• Modeling fimbriae mediated parasite-host interactions

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