A model of host response to a multi-stage pathogen

DOI10.1007/S00285-010-0365-5MaRDI QIDQ659020zbMATH OpenOpenAlexWikidataFDO

Authors Juan-Miguel Gracia

Publication date 9 February 2012

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1005.0332, http://europepmc.org/articles/pmc3095709

zbMATH Keywords

immunologyHost-pathogen interactionsModels of microepidemics

Mathematics Subject Classification ID

Medical epidemiology (92C60) Partial orders, general (06A06) Qualitative investigation and simulation of ordinary differential equation models (34C60) Dynamical systems in biology (37N25)

Abstract: We model the immune surveillance of a pathogen which passes through $n$ immunologically distinct stages. The biological parameters of this system induce a partial order on the stages, and this, in turn, determines which stages will be subject to immune regulation. This corresponds to the system's unique asymptotically stable fixed point.

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Cites work

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Cited in

(5)

• An in-host model of acute infection: measles as a case study
• Etiology of IRF models
• Synergy of local, regional, and systemic non-specific stressors for host defense against pathogens
• Marchuk's models of infection diseases: new developments
• Modeling fimbriae mediated parasite-host interactions

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